THE EFFECT OF REPEATED COMPRESSION AND CONCENTRATION OF MALTODEXTRIN AS A BINDER ON THE QUALITY OF CALCIUM LACTATE TABLETS
Lestari, A., Chusien, A. (2025). THE EFFECT OF REPEATED COMPRESSION AND CONCENTRATION OF MALTODEXTRIN AS A BINDER ON THE QUALITY OF CALCIUM LACTATE TABLETS. EKB Journal Management System, (), -. doi: 10.21608/bfsa.2025.372336.2496
Agatha Budi Susiana Lestari; Adhita Wicaksaneng Naya Brena Chusien. "THE EFFECT OF REPEATED COMPRESSION AND CONCENTRATION OF MALTODEXTRIN AS A BINDER ON THE QUALITY OF CALCIUM LACTATE TABLETS". EKB Journal Management System, , , 2025, -. doi: 10.21608/bfsa.2025.372336.2496
Lestari, A., Chusien, A. (2025). 'THE EFFECT OF REPEATED COMPRESSION AND CONCENTRATION OF MALTODEXTRIN AS A BINDER ON THE QUALITY OF CALCIUM LACTATE TABLETS', EKB Journal Management System, (), pp. -. doi: 10.21608/bfsa.2025.372336.2496
Lestari, A., Chusien, A. THE EFFECT OF REPEATED COMPRESSION AND CONCENTRATION OF MALTODEXTRIN AS A BINDER ON THE QUALITY OF CALCIUM LACTATE TABLETS. EKB Journal Management System, 2025; (): -. doi: 10.21608/bfsa.2025.372336.2496

THE EFFECT OF REPEATED COMPRESSION AND CONCENTRATION OF MALTODEXTRIN AS A BINDER ON THE QUALITY OF CALCIUM LACTATE TABLETS

Bulletin of Pharmaceutical Sciences Assiut University
Articles in Press, Accepted Manuscript, Available Online from 15 July 2025  XML
Document Type: Original Article
DOI: 10.21608/bfsa.2025.372336.2496
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Authors
Agatha Budi Susiana Lestari email orcid 1; Adhita Wicaksaneng Naya Brena Chusien2
1Department of Pharmaceutical, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
2Faculty of Pharmacy, Sanata Dharma University, Yogyakarta 55282, Indonesia
Abstract
Objectives: This study aims to determine the effect of recompression frequency and differences in maltodextrin concentration on the physical properties of the granule mixture and the physical properties of calcium lactate tablets, and to determine the relationship between recompression frequency and maltodextrin concentration on the physical properties of the granule mixture and the physical properties of calcium lactate tablets.

Material and Methods: Calcium lactate was compressed into tablets with varying concentrations of maltodextrin as a binder and repeatedly compressed. Tablets were prepared using the wet granulation method. The physical properties of the powder mixture (flowability, compressibility) and the physical properties of the tablets (organoleptic, weight uniformity, active substance content, hardness, friability, and disintegration time) were tested.

Results: The results showed that variations in maltodextrin concentration and recompression significantly affected the some of the physical properties of calcium lactate powder and tablet. Statistical analysis showed significant differences in flow rate, compressibility, tablet hardness, friability, and tablet disintegration time.

Conclusion: Repeated compression frequency does not affect tablet hardness; and maltodextrin concentration does not affect the compressibility of the mixture and tablet hardness.
Keywords
recompression; tablet excipient; physical properties of tablet
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