Role of Interleukin-1β and Prostaglandin E2 in Prediction and Outcome of Apnea in Neonates | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 15 July 2025 PDF (536.34 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.369872.2350 | ||
| Authors | ||
| Wesam E Afifi1; Omima M Abdel Haie2; Asmaa A Alfallah3; Sara K Moharm* 4; Amany M El-Rebigi2 | ||
| 1Department of Pediatrics and Neonatology, Faculty of Medicine – Benha University | ||
| 2Department of pediatrics and neonatology, Faculty of Medicine- Benha University | ||
| 3Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt. | ||
| 43- M.B.B. Ch, Faculty of medicine- Al Azhar University | ||
| Abstract | ||
| Background: It has been hypothesized that inflammatory processes may have a biological role in the pathway of apneas of prematurity (AOP). On a molecular basis, these processes are regulated by a variety of mediators. Methods: To stipulate the precise utility of interleukin-1β (IL-1β) and prostaglandin E2 (PGE2), quantitative measurement of these inflammatory mediators was determined using specific ELISA techniques in the serum of 100 preterm babies. The neonates were grouped into two categories (apneic and non-apneic). Results: A considerable positive correlation was detected between serum IL-6 and PGE2 (r = 0.470 and P-value < 0.001). Our data showcased that AOP happened with a PGE2 cutoff value > 387.3 pg/ml, an area under the curve (AUC) of 0.733, indicating a sensitivity of 64% and a specificity of 62%. Also, the cutoff value for IL-1β that led to the occurrence of AOP was > 1246.5 pg/ml, the AUC was 0.813, and the corresponding sensitivity and specificity were 80% and 72%, respectively. The stepwise multivariate model showcased that hemoglobin level, C-reactive protein (CRP), PGE2, and IL-1β levels were independent predictors for AOP with an odds ratio (95% CI) [0.44 (0.08–0.89), 1.49 (0.98–1.93), 1.02 (1.05–1.09), and 1.02 (1.08–1.44)], respectively. Conclusion: This thesis emphasizes how IL-6 and PGE2 may assist in predicting apneic episodes in preterm neonates. Therefore, preemptive interventions can be designated to lessen the incidence and severity of AOP. | ||
| Keywords | ||
| Apnea of prematurity; Interleukin-1β; Prostaglandin E2; Outcome | ||
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