Study the value of Fecal Calprotectin in neonate with congenital heart disease and necrotizing enterocollitis | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 15 July 2025 PDF (423.23 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.378475.2381 | ||||
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| Authors | ||||
Somaia A Elwan1; Abeer E Karish  2; Maha M Osman 3; Eman G Abdelrahman 4
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| 1Department of pediatrics , Faculty of Medicine, Banha University, Banha, Egypt | ||||
| 2M.B.B.CH. pediatrics Department, Faculty of Medicine, Banha University, Banha, Egypt | ||||
| 3Department of Clinical and Chemical Pathology , Faculty of Medicine, Banha University, Banha, Egypt | ||||
| 4Department of pediatrics , Faculty of Medicine, Banha University, Banha, Egypt | ||||
| Abstract | ||||
| Background: Neonates with congenital heart disease (CHD) are more risky for suspected necrotizing enterocolitis (NEC) due to reduced cardiac output causing decreased mesenteric blood flow and gut ischemia. Fecal calprotectin levels are elevated in infectious and inflammatory illnesses like NEC. The purpose of this work was to assess the role of Fecal calprotectin in the early recognition of suspected NEC in infants with CHD. Methods: This case control research has been performed on 80 neonates, both sexes, divided into 3 groups: group 1: CHD whether cyanotic or a cyanotic, group 2: CHD with suspected NEC (abdominal distention, gastric residual, bloody stool), group 3: control healthy group. Radiological and laboratory investigations were done. Fecal calprotectin marker was measured at time of suspecting NEC and were correlated to gestational age, weight, length, vital signs, other laboratory markers. Results: Fecal calprotectin level, C-reactive proteins, prothrombin time, international normalized ratio and serum glutamic-pyruvic transaminase were significantly greater in the CHD and suspected NEC group, there is a significant negative association has been observed among fecal calprotectin and weight (r = -0.449, P-value equal to 0.047) and creatinine (r = -0.454, P = 0.044) in this group. Additionally, fecal calprotectin was a significant predictor of CHD with suspected NEC, controlling for gestational age, sex, weight, and type of feeding. Conclusions: Neonates with CHD and suspected NEC had higher level of fecal calprotectin than other groups. Fecal calprotectin was an effective early predictor of NEC in neonates with CHD with 90% sensitivity, and 92.5% specificity. | ||||
| Keywords | ||||
| Fecal Calprotectin; Congenital Heart Disease; Necrotizing Enterocolitis; Neonates | ||||
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