AMELIORATIVE EFFECTS OF LYCOPENE ON AFLATOXIN-B1 TOXICITY IN BROILER CHICKENS

HASSAN, R.A.; MOUSA, M.A.M.; KHOSHT, ABEER RABIE; SALIM, IBRAHIM H.; SHAMSELDEEN, AHMED. E.; ARAFA, AHMED S.; EL-DEEB, MAGED A.; EL-KOMY, HAMDY M.; MOBAREZ, SAMIA M

doi:10.21608/avmj.2025.358556.1574

	AMELIORATIVE EFFECTS OF LYCOPENE ON AFLATOXIN-B1 TOXICITY IN BROILER CHICKENS
Assiut Veterinary Medical Journal
Article 14, Volume 71, Issue 186, July 2025, Page 178-194 PDF (655.23 K)
Document Type: Review article
DOI: 10.21608/avmj.2025.358556.1574
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Authors
R.A. HASSAN ¹; M.A.M. MOUSA¹; ABEER RABIE KHOSHT¹; IBRAHIM H. SALIM¹; AHMED. E. SHAMSELDEEN¹; AHMED S. ARAFA¹; MAGED A. EL-DEEB¹; HAMDY M. EL-KOMY¹; SAMIA M MOBAREZ²
¹Animal Production Research Institute, Agricultural Research Center, Dokki, Giza, Egypt.
²Animal Production Research Institute, Agricultural Research Center, Dokki, Giza, Egypt
Abstract
The purpose of this study was to investigate the effects of adding varying amounts of lycopene (100, 200 and 400) mg/kg to broiler's diets contaminated with aflatoxin B1 (300 µg/kg) on growth and physiological performance. In a completely randomized design, three hundred unsexed, one-day-old Ross chicks were split into five treatments, each with six replicates (10 chicks per duplicate). All diets were created to meet the according to Ross Guide. Broilers were given unlimited access to feed and water. The results showed that adding lycopene to diets tainted with aflatoxin B1 significantly improved growth and cellular blood parameters, without negatively affecting the birds' health. Additionally, the results showed that lycopene supplementation decreased serum levels of low-density lipoproteins, triglycerides, cholesterol, and uric acid or creatinine in birds fed mycotoxin-contaminated diets. Moreover, increased high-density lipoprotein levels, which are thought to be a reliable predictor of blood lipid readings. The addition of lycopene enhanced the functions of the liver enzymes ALT and AST, as well as the concentrations of glucose, total protein, globulin, albumin, and antioxidant activities. The aflatoxin B1 residue in the liver and meat tissues of broiler chickens was also decreased. The present findings highlight the preventive role of lycopene supplementation in protecting against aflatoxin-contaminated diets and diminishing their harmful effect on the growth, physiological performance and health status of broiler chickens.
Keywords
Aflatoxin B1; Lycopene; broiler chickens; oxidative status


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