Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats
A. Amin, A., M. Hassan, N., O. Aboraya, A. (2023). Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats. EKB Journal Management System, 39(2), 29-44. doi: 10.21608/jhe.2023.442197
Ahmed A. Amin; Nehal M. Hassan; Alaa O. Aboraya. "Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats". EKB Journal Management System, 39, 2, 2023, 29-44. doi: 10.21608/jhe.2023.442197
A. Amin, A., M. Hassan, N., O. Aboraya, A. (2023). 'Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats', EKB Journal Management System, 39(2), pp. 29-44. doi: 10.21608/jhe.2023.442197
A. Amin, A., M. Hassan, N., O. Aboraya, A. Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats. EKB Journal Management System, 2023; 39(2): 29-44. doi: 10.21608/jhe.2023.442197

Antioxidant and Hepatoprotective effect of Senna leaves (Cassia senna l.) against carbon tetrachloride induced hepatotoxicity in rats

مجلة الاقتصاد المنزلي
Volume 39, Issue 2, June 2023, Pages 29-44    PDF (507.07 K)
Document Type: المقالة الأصلية
DOI: 10.21608/jhe.2023.442197
Authors
Ahmed A. Amin1; Nehal M. Hassan1; Alaa O. Aboraya2
1Nutrition and Food Sciences Dept., Faculty of Home Economics-Helwan University- Egypt
2Nutrition Science Faculty – Helwan University – Egypt
Abstract
The present study was designed to investigate the antioxidant and hepatoprotective effects of Senna leaves on carbon tetrachloride (CCl4) induced rats hepatotoxicity. A total of 28 adult male Sprague Dawley albino rats (150 ± 10 g) were obtained from the Experimental Animals Farm, Helwan, Egypt. The first group (n=7) served as the negative control and received a standard basal diet. The second group (n=21) was intraperitoneally injected with carbon tetrachloride (CCl₄) at a dose of 1 mL/kg (1:1 in corn oil) for 3 consecutive days to induce hepatotoxicity. Hepatotoxic rats were then subdivided into three groups (n=7 each): a positive control group fed the basal diet only, and two treatment groups receiving the basal diet supplemented with either 1% or 2% of senna leaves. Biological evaluation parameters were determined (IBW, FBW, FER, BWG%) for rats. Blood samples were separated into serum for liver functions determination (ALT, AST and ALP) , lipid profile parameters (TC, TG, HDL-C, LDL-C and VLDL-C) and antioxidant parameters determination (MDA and GPx). The increase in IBW, FBW, BWG% and FER were significantly ameliorated by the administration of Senna leaves treatments, compared to hepatotoxicity rats. The results revealed that in CCl4 group, there were significant increases in ALT, AST, ALP ,TC, TG, LDL-C , VLDL-C and MDA, while parameters HDL-C and GPx showed significant decreases. Meanwhile, administration of Senna leaves resulted in a significant decrease in all elevated mentioned parameters and increase in HDL and GPx. Therefore, it could be concluded that Senna leaves have hepatoprotective and antioxidant role.   
Keywords
Senna leaves; CCl4 hepatotoxicity; antioxidant; hepatoprotective
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