The Influence of Allium sativum and Syzygium aromaticum Powder Supplementation on Biochemical Markers, Oxidative Stress, and Histopathological Features of Albino Rats' Liver and Kidney Functions
R. Bakeer, M., Seifelnasr, E., M. Ibrahim, M., Hassanen, E., Kh. Hendawy, A. (2025). The Influence of Allium sativum and Syzygium aromaticum Powder Supplementation on Biochemical Markers, Oxidative Stress, and Histopathological Features of Albino Rats' Liver and Kidney Functions. EKB Journal Management System, (), 1-9. doi: 10.21608/ejvs.2025.384611.2839
Manal R. Bakeer; Esmat Seifelnasr; Marina M. Ibrahim; Eman I. Hassanen; Aya Kh. Hendawy. "The Influence of Allium sativum and Syzygium aromaticum Powder Supplementation on Biochemical Markers, Oxidative Stress, and Histopathological Features of Albino Rats' Liver and Kidney Functions". EKB Journal Management System, , , 2025, 1-9. doi: 10.21608/ejvs.2025.384611.2839
R. Bakeer, M., Seifelnasr, E., M. Ibrahim, M., Hassanen, E., Kh. Hendawy, A. (2025). 'The Influence of Allium sativum and Syzygium aromaticum Powder Supplementation on Biochemical Markers, Oxidative Stress, and Histopathological Features of Albino Rats' Liver and Kidney Functions', EKB Journal Management System, (), pp. 1-9. doi: 10.21608/ejvs.2025.384611.2839
R. Bakeer, M., Seifelnasr, E., M. Ibrahim, M., Hassanen, E., Kh. Hendawy, A. The Influence of Allium sativum and Syzygium aromaticum Powder Supplementation on Biochemical Markers, Oxidative Stress, and Histopathological Features of Albino Rats' Liver and Kidney Functions. EKB Journal Management System, 2025; (): 1-9. doi: 10.21608/ejvs.2025.384611.2839

The Influence of Allium sativum and Syzygium aromaticum Powder Supplementation on Biochemical Markers, Oxidative Stress, and Histopathological Features of Albino Rats' Liver and Kidney Functions

Egyptian Journal of Veterinary Sciences
Articles in Press, Accepted Manuscript, Available Online from 16 July 2025  XML PDF (621.16 K)
Document Type: Original Article
DOI: 10.21608/ejvs.2025.384611.2839
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Authors
Manal R. Bakeer email 1; Esmat Seifelnasr1; Marina M. Ibrahim1; Eman I. Hassanen2; Aya Kh. Hendawy1
1physiology department vet medicine cairo university. egypt
2pathology department vet medicine cairo university. egypt
Abstract
The garlic (Allium sativum) and clove (Syzygium aromaticum) are widely recognized for their medicinal and antioxidant properties. Thirty adult male Swiss albino rats (average body weight 150 - 170 gm.) divided into three groups and examined for two months.  Group 1 (control group) was fed a conventional rat diet, Group 2 was given 5% garlic powder in their usual meal, and Group 3 was given 30 mg/kg BWT of clove powder every day.  Biochemical investigation revealed significant decrease in AST levels in supplemented groups compared to the control. Kidney function indicators indicated a substantial decrease in uric acid, creatinine, and urea levels in the garlic-supplemented group, but no significant changes observed in the clove group.  Oxidative stress study demonstrated a substantial increase in total antioxidant capacity in the garlic-treated group, as well as a decrease in malondialdehyde (MDA) levels in both the garlic and clove-treated groups.  In addition, both treatment groups had considerably enhanced superoxide dismutase (SOD) activity.  Histopathological analysis of liver and kidney tissues revealed no structural abnormalities in either group, suggesting no negative impact on organ morphology. These findings highlight the potential of garlic and clove supplementation in enhancing antioxidant defense mechanisms and improving certain biochemical markers of liver and kidney function.
Keywords
Garlic; Clove; Antioxidant; Oxidative Stress; Liver Function; Kidney Function; Superoxide Dismutase; Malondialdehyde; Total Antioxidant Capacity
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