Helicobacter pylori and its potential relationship to Ischemic Heart Disease | ||||
| Sohag Medical Journal | ||||
| Volume 29, Issue 2, 2025, Page 171-177 PDF (985 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/smj.2025.383554.1569 | ||||
 View on SCiNiTO | ||||
| Author | ||||
mohammed khalaf morsi 
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| internal medicine department, sohag faculty of medicine, sohag university , sohag , Egypt | ||||
| Abstract | ||||
| ABSTRACT Helicobacter pylori (H. pylori) is a common bacterium that causes a variety of gastrointestinal and duodenal illnesses. It was traditionally believed that H. pylori infection only affected the digestive system, but recent studies show that it can impact general health and contribute to the development of several non-gastric disorders, including ischemic heart disease (IHD). Because IHD is an important cause of mortality and disability worldwide, it is essential to identify other risk factors for IHD beyond the traditional ones associated with cardiovascular disease. This article provides a concise overview of the current literature regarding the potential association between H. pylori infection and IHD. We investigate the hypothesized biological pathways that connect Helicobacter pylori to heart disease, which include systemic inflammatory response, molecular mimicry, platelet activation, and differences in lipid profiles. We provide a critical review of the epidemiological studies that have looked into this link, drawing attention to the results that are both consistent with and inconsistent with one another. We go on to talk about the research gaps, clinical consequences, and future directions for understanding the intricate interplay between H. pylori and IHD. In order to encourage more study in this dynamic area, this review provides a thorough and fair assessment of the current data. | ||||
| Keywords | ||||
| Ischemic Heart Disease; Inflammation; Helicobacter pylori Infection; Epidemiology; Risk Factors | ||||
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