Evaluation of some physiological biomarkers among Egyptian women with uterine fibroids. | ||||
| Alfarama Journal of Basic & Applied Sciences | ||||
| Articles in Press, Accepted Manuscript, Available Online from 16 July 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajbas.2025.393011.1261 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Afaf M. Mohamed Elsaid 1; Yassmeen Mohamed Elsayed  2; Ali Hussein Abu Almaaty 3; Mohamed Ibrahim Eid 4; Ahmed Khalaf Hasan 5
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| 1Afaf Mohamed Elsaid, Biochemistry department, Faculty of medicine , Mansoura university, Mansoura,35511,Egypt. | ||||
| 2Chemistry and Zoology division,Zoology department,portsaid university, Port said , 42522,Egypt | ||||
| 3Ali Hussein Abu Almaaty, Zoology department, Faculty of science, Port said university, Port said , 42522,Egypt. | ||||
| 4Mohamed Ibrahim Eid , Genecology Department, Faculty of medicine ,Mansoura university, Mansoura,35511,Egypt. | ||||
| 5Department of Zoology, Faculty of Science, Port Said University | ||||
| Abstract | ||||
| Uterine fibroids are nonmalignant monoclonal neoplasms of the myometrium, constituting the most prevalent tumors among women globally. A total of one hundred women with fibroids and one hundred apparently healthy controls were evaluated for biochemical and hematological measurements including serum prolactin, CA 125, LDH levels and other biochemical parameters as well as complete blood picture. Relevant demographic, medical history and clinical presentation of studied subjects were obtained for all the participants. Fibroid women presented with specific characteristics. The median weight and BMI of fibroid patient were markedly superior than in the control group (p<0.001 for both). It was detected that 31% of women had a family history of fibroid, while 26% had previous abortion. In addition, 12% of women formerly underwent fibroid removal operations. Vaginal bleeding was present in 66% of the females. In addition, 34% of the cases suffered from abdominal and pelvic pain. Furthermore, the lab investigations revealed that the mean hemoglobin level in the fibroid group (10.66 ± 1.77 g/dl) was markedly inferior than the control group (11.63 ± 1.26 g/dl), p<0.001. The LDH activity was considerably elevated among the fibroid patients, whereas the serum albumin and total protein levels were considerably diminished compared to the controls (p<0.001 for all). The mean prolactin concentration was markedly elevated in the fibroid group than in the controls (43.05 vs.14.0 ng/mL, respectively, p<0.001). In conclusions, detection of serum some serum parameters such as serum prolactin, LDH, total proteins and CA125 levels are important markers characterizing uterine fibroids . | ||||
| Keywords | ||||
| Keywords: Uterine fibroids; risk factors; hormonal status; biomarkers | ||||
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