Association of Helicobacter pylori IgG with Type 2 Diabetes in Iraqi Patients | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 January 2026 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.403018.1772 | ||
| Authors | ||
| Sura Q. Ali* ; Dunya F. Salloom | ||
| Department of Biology, College of Sciences, University of Baghdad, Baghdad, Iraq | ||
| Abstract | ||
| Background: Diabetes mellitus (DM) is a prevalent and devastating chronic condition, with rising incidence globally and in Iraq. Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevation in blood glucose related to insulin resistance or insulin deficiency. Helicobacter pylori (H. pylori) is a gram-negative bacterium that can cause gastric and extra-gastric diseases such as Chronic gastritis, peptic ulcer, and gastric cancer. Objective: The study aimed to determine the association between H. pylori infection and the progression of T2DM by investigating H. pylori IgG concentrations in T2DM patients compared to controls. Methodology: This study was conducted in Baghdad city between October 2023 and April 2024, and included 100 individuals, 40 as a control group and 60 patients (29 males and 31 females) suffering from T2DM with H. pylori infection. The serum sample was divided into two parts; one aliquot was utilised to assess fasting blood glucose (FBG), the remaining fraction was stored at -20°C for H. pylori IgG analysis by ELISA. Results: The means age of T2DM patients and control group were 46.63 ± 1.63 vs 44.90 ± 2.08 years, respectively and there was non significant difference between groups. BMI means of T2DM, and control group were (27.47 ± 0.63 vs 26.93 ± 0.75) Kg/m2, respectively. FBG mg/dL was elevated in T2DM compared to controls (172.1 ± 58.07 versus 102.3 ± 18.81) mg/dL, respectively. H. pylori IgG concentration of T2DM and control group was (22.89 ± 0.91 vs 6.91 ± 0.79) pg/ml, respectively with high significant difference between two groups (p < 0.001). H. pylori IgG concentration reported high levels in T2DM patients with obesity and elderly patients (23.86 ± 6.7; 25.85 ± 4.5) pg/ml, respectively. Conclusions: According to the results of this study H. pylori IgG levels was higher in the T2DM with BMI >30 and elderly T2DM patients and serum H. pylori IgG levels in diabetic patients was higher than non- diabetics subjects. | ||
| Keywords | ||
| T2DM; Helicobacter pylori; H. pylori IgG concentration; FBG | ||
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