Study of Some Inflammatory Biomarkers Associated with Stress Pre Operation in Iraqi Patients | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 53, Volume 35, Issue 1, January 2026 | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2025.402346.1766 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nawar R. Jaber  1; Sara S. Rasheed2; Sura S. Talib3; Zahraa A. Abed3; Hazzim I. Abdilbari3
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| 11Biotechnology Research Center, Environmental Biotechnologies Department, Al-Nahrain University, Baghdad, Iraq | ||||
| 2College of Science, Department of Biology, Al-Nahrain University, Baghdad, Iraq | ||||
| 3Biotechnology Research Center, Environmental Biotechnologies Department, Al-Nahrain University, Baghdad, Iraq | ||||
| Abstract | ||||
| Background: Psychological and social factors, as well as internal and external environmental factors, can significantly affect mental health, any stimulus that can disturb biological processes is defined as stress, one of many causes that generates this psychological pressure is surgery, it can inherently induce stress and trauma, leading to notable hormonal and metabolic alterations in the body. Objectives: this study aimed to investigate the impairment of immune-inflammatory traits, oxidative stress markers, and hematological parameters in Iraqi patients experiencing preoperative stress to elucidated the multifaceted physiological impact of this phenomenon. Methodology: blood and serum samples were collected from 50 patients presenting to the emergency department (ED) who required emergency surgical intervention, and 50 healthy controls were included in this study. From all cases, blood and serum samples were tested for antioxidant levels of SOD and MDA, immunological marker TNF-Alpha, and CBC: WBC, LYM, Neut and PLT, and CRP in serum. Results: statistical analysis revealed significant differences between patient and control groups. Patients exhibited markedly decreased SOD levels, alongside significantly increased MDA levels and TNF-Alpha levels. Furthermore, patients showed elevated WBC count. Most patients also tested positive for CRP, indicating systemic inflammation. Conclusion: these findings collectively demonstrate that preoperative stress in Iraq patients induces a significant physiological impact, characterized by oxidative stress, heightened immune-inflammatory response, and altered hematological profiles. Our results underscore the importance of addressing preoperative stress to potentially mitigate these adverse biological changes and improve patient outcome. | ||||
| Keywords | ||||
| Stress; Surgery; WBC; SOD; MDA | ||||
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