The Significant of mi-RNA223 and serum levels of IL-17A and IL-10 in Psoriasis and Psoriatic Arthritis Iraqi patients | ||
| Egyptian Journal of Medical Microbiology | ||
| Articles in Press, Accepted Manuscript, Available Online from 01 January 2026 | ||
| Document Type: New and original researches in the field of Microbiology. | ||
| DOI: 10.21608/ejmm.2025.397231.1736 | ||
| Authors | ||
| Amer A. Alkilabi* ; Israa A. Dheeb | ||
| Medical Microbiology Department, College of Medicine, University of Al-Qadisiyah, Iraq | ||
| Abstract | ||
| Background: Psoriasis (PS) is a chronic, multifactorial autoimmune skin disease with systemic involvement. Around 30% of PS patients develop psoriatic arthritis (PsA) within 10 years, characterized by musculoskeletal inflammation, including arthritis, enthesitis, dactylitis, and osteitis.Objective: To identify diagnostic immunomarkers particularly IL-10, IL-17A and their association with miRNA223 for early prediction of PS and PsA Methodology: The study assessed serum levels of IL-10, IL-17A, and gene expression of miRNA223 in 40 PS patients, 40 PsA patients, and 40 healthy controls. Results: Mean IL-10 levels were 1.76 ± 0.12 (PS), 5.71 ± 0.17 (PsA), and 2.91 ± 0.13 (controls), with a highly significant difference (P < 0.001). A cut-off value <2.35 yielded an AUC of 1.000 (CI 95%, P=0.001) with 100% sensitivity, specificity, PPV, and NPV. IL-17A levels were also significantly elevated in patient groups: 122.79 ± 19.29 (PS), 95.35 ± 20.2 (PsA) vs. 38.94 ± 6.34 (controls), with P < 0.001. A cut-off >74.41 gave an AUC of 1.000, with 100% diagnostic accuracy. miRNA223 expression was significantly upregulated in both PS (fold change 9.24) and PsA (fold change 4.11) compared to controls. Conclusion: L-10 and IL-17A show excellent diagnostic accuracy for PS and PsA. Additionally, miRNA223 plays a critical role in the pathogenesis and may serve as a marker for early detection and disease severity. | ||
| Keywords | ||
| Psoriasis; psoriatic arthritis; IL-17A; miRNA-223; Area under curve | ||
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