Splenotoxicity of carbendazim and role of date palm pollen as a therapeutic agent in male albino rats | ||
| Journal of Environmental Studies | ||
| Volume 39, Issue 1, September 2025, Pages 1-9 PDF (1.88 M) | ||
| Document Type: High quality original papers | ||
| DOI: 10.21608/jesj.2025.401077.1140 | ||
| Authors | ||
| Basma Hammed Hammad1; Mohamed Farag El-Sayed2; Sary Kh. Abd-elghaffar3; Ahmed Badr* 1 | ||
| 1Zoology Department, Faculty of Science, Sohag University, Sohag, Egypt | ||
| 2Zoology Department, Faculty of science, Sohag university , Sohag , Egypt | ||
| 3Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt; School Of Veterinary Medicine ,Badr University, Assiut, Egypt | ||
| Abstract | ||
| Among fungicides, carbendazim (CBZ) is a widely used fungicide against a broad spectrum of fungal diseases. The widespread use of CBZ has raised concerns regarding its environmental persistence and potential toxicological effects on non-target organisms. To the best of our knowledge, CBZ toxicity on spleen, plays a vital role in the lymphatic and immune systems, wasn’t documented. Therefore, we examine the chronic exposure of sub-lethal concentration of CBZ on histological structure of spleen in rats. Moreover, we examine the therapeutic potential effect of date palm pollen (DPP) in counteracting CBZ toxicity. 32 of male albino rats (Rattus rattus) were divided into 4 groups: control, CBZ (10 mg/Kg.bw), DPP (100 mg/Kg.bw), and CBZ with DPP; and exposure experiment was lasted for 2 months. CBZ caused severe histopathological changes in spleen structure as hemorrhagic infarction, severe congestion, dilatation of splenic sinuses, fibrosis and lymphoid cells depletion in white pulp; and hemorrhage in the red pulp. Treatment with DPP alone showed normal spleen structure as control; while it seems that DPP soothes the negative effects of CBZ when combined together, and shows mostly normal structure of spleen with exception of mild necrotic lymphoid cells in white pulp; hemosidrosis and infarction in red pulp. The capacity of DPP to soothe CBZ toxicity might return to its chemical composition that enhance the ability to detoxify harmful substances by neutralizing ROS that might be generated during CBZ exposure. However, future biochemical and physiological studies are needed to examine CBZ toxicity and the therapeutic efficiency of DPP. | ||
| Keywords | ||
| carbendazim; natural products; spleen; pesticide; immune system | ||
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