EXPLORING THE POTENTIAL ROLE OF AMPHORA COFFEAEFORMIS AND PROPOLIS IN MITIGATION OF NEUROTOXICITY INDUCED BY FLUMETHRIN IN RATS | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 9, Volume 71, Issue 186, July 2025, Page 117-134 PDF (1.42 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2025.368158.1627 | ||||
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| Authors | ||||
ASMAA R. MOHAMED1; TOHAMY M. A1; ABEER M. RADI1; RANDA M. HASSAN 2; MARWA A. IBRAHIM3; NEMA S. SHABAN  4
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| 1Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt | ||||
| 2Department of Cytology and Histology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt. | ||||
| 3Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt | ||||
| 4Pharmacology department, Faculty of veterinary medicine, Beni-suef University, Beni-suef, Egypt | ||||
| Abstract | ||||
| Flumethrin, a synthetic pyrethroid insecticide, is used to manage a variety of insects, including mites, fleas, and ticks. This study was conducted to investigate the possible neuroprotective potential of Amphora coffaeformis and Propolis against Flumethrin-induced neurotoxicity in rat. Sixty male albino rats were allocated into six equal groups as follow: Group 1: (Control group), Group 2: was received Flumethrin (10 mg/kg b.w.), Group 3: was received Amphora coffeaformis (772 mg/kg b.w.), Group 4: was received Propolis (400 mg/kg b.w.), Group 5: was received Amphora coffeaformis (772 mg/ kg b.w.) followed by Flumethrin (10 mg/kg b.w.) one hour later, Group 6: was given Propolis (400 mg/kg b.w.) followed by Flumethrin (10 mg/kg b.w.) one hour later. The medications were given orally by an intragastric gavage once daily for thirty days. After one month, rats were sacrificed; serum and brain samples were collected for biochemical, molecular and histopathological analysis. The results revealed that Flumethrin exposure precipitated a cascade of oxidative stress, evidenced by elevated malondialdehyde (MDA) levels, diminished catalase (CAT) and glutathione (GSH) activities, and dysregulated Nrf-2, AChE, and TNFα expression. Conversely, Amphora coffaeformis and Propolis supplementation exerted a neuroprotective effect, mitigating MDA accumulation, augmenting CAT and GSH activities, and modulating TNFα, Nrf-2, and AChE expression. In conclusion, Amphora coffaeformis and Propolis may serve as natural neuroprotective agents, counteracting Flumethrin-induced neurotoxicity through their antioxidant and anti-inflammatory properties. | ||||
| Keywords | ||||
| Amphora coffeaformis; Propolis; Flumethrin; antioxidant; gene expression | ||||
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