Prevalence and risk factors of Extended-Spectrum Beta-Lactamase production and carbapenem resistance among community-acquired Gram-negative Uropathogens
Alkhawagah, S., Elattar, S., Ahmed, R. (2025). Prevalence and risk factors of Extended-Spectrum Beta-Lactamase production and carbapenem resistance among community-acquired Gram-negative Uropathogens. EKB Journal Management System, (), -. doi: 10.21608/mid.2025.396024.2922
Sabah M. Alkhawagah; Shaimaa Elattar; Rasha Ahmed. "Prevalence and risk factors of Extended-Spectrum Beta-Lactamase production and carbapenem resistance among community-acquired Gram-negative Uropathogens". EKB Journal Management System, , , 2025, -. doi: 10.21608/mid.2025.396024.2922
Alkhawagah, S., Elattar, S., Ahmed, R. (2025). 'Prevalence and risk factors of Extended-Spectrum Beta-Lactamase production and carbapenem resistance among community-acquired Gram-negative Uropathogens', EKB Journal Management System, (), pp. -. doi: 10.21608/mid.2025.396024.2922
Alkhawagah, S., Elattar, S., Ahmed, R. Prevalence and risk factors of Extended-Spectrum Beta-Lactamase production and carbapenem resistance among community-acquired Gram-negative Uropathogens. EKB Journal Management System, 2025; (): -. doi: 10.21608/mid.2025.396024.2922

Prevalence and risk factors of Extended-Spectrum Beta-Lactamase production and carbapenem resistance among community-acquired Gram-negative Uropathogens

Microbes and Infectious Diseases
Articles in Press, Accepted Manuscript, Available Online from 17 July 2025  XML
Document Type: Original Article
DOI: 10.21608/mid.2025.396024.2922
View on SCiNiTO View on SCiNiTO
Authors
Sabah M. Alkhawagah email orcid 1; Shaimaa Elattarorcid 2; Rasha Ahmedorcid 3
1Medical Microbiology and Immunology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt
2Clinical Pathology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt
3Urology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt
Abstract
Background: Community-acquired urinary tract infections (UTIs) are considered one of the most frequent bacterial infections. The increasing threat of extended-spectrum beta-lactamase (ESBL) production and carbapenem resistance has significantly impacted the management of these infections. This study aimed to determine the prevalence and identify the risk factors of ESBL production and carbapenem resistance among community-acquired UTIs. Methods: This study was conducted on 385 outpatient urine samples that were inoculated aerobically. Significant bacterial isolates were identified conventionally and confirmed using the VITEK® 2 compact system. Antimicrobial susceptibility testing (AST) was performed using the Kirby-Bauer disk diffusion method. ESBL production was detected phenotypically using the Double Disc Synergy Test (DDST). Results: A total of 141 Gram-negative isolates were recovered. Escherichia coli (59.6%) was the most frequent pathogen. The overall multidrug resistance (MDR) rate was 66.7%. ESBL production was detected in 42 isolates of E. coli and K. pneumoniae at rates of 35.7% and 42.9%, respectively. MDR (P-value<0.001) and ESBL production (P-value=0.006) were significantly higher in Klebsiella pneumoniae. Carbapenem resistance was detected in 19.1% (27/141) of the isolates. Isolates recovered from diabetic patients were most probably to produce ESBLs and exhibit carbapenem resistance [OR=2.579; 95% CI: 0.981, 6.784; P-value=0.049]. Conclusion: Considerable rates of MDR, ESBL production, and carbapenem resistance were reported among the community-acquired UTIs. Microbiological guided treatment and strategic antibiotic use are recommended for controlling the rise of antimicrobial resistance (AMR) in the community.
Keywords
Community-acquired infections; UTIs; Antimicrobial resistance; ESBL; Carbapenem resistance
Statistics
Article View: 65