α-Lipoic acid protects against γ-rays-induced cardiac injury in rats | ||||
| Egyptian Journal of Radiation Sciences and Applications | ||||
| Volume 38, Issue 1, December 2025, Page 39-49 PDF (972.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejrsa.2025.374406.1183 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sameh S. Tawfik   1; Rehab M. Ebraheim1; Wael A. El khouly2
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| 1Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, P.O. Box, 29 Nasr City, Cairo, Egypt. | ||||
| 2Radiation Protection Department, Nuclear and Radiation Safety Research Center (NRSRC), Egyptian Atomic Energy Authority, P.O. Box, 29 Nasr City, Cairo, Egypt. | ||||
| Abstract | ||||
| α-Lipoic acid is found in some mammalian and plant tissues. It has antioxidant and anti-inflammatory effects. The objective of this study was to test the hypothesis that oral administration of α-lipoic acid causes protection against cardiac injury in γ-irradiated rats. A group of rats was exposed to a single session of 6 Gy γ-rays and compared with three other groups: a control group (received vehicle only), an α-lipoic acid-treated group (received 100 mg/kg body weight orally for 10 days), and a combined treatment group (received 6 Gy γ-radiation along with α-lipoic acid for 10 days). The effect of radiation was indicated by an increase in the activity of lactate dehydrogenase (LDH), creatin Kinase MB (CK-MB), myeloperoxidase (MPO), xanthine oxidase (XO), malondialdehydes (MDA), protein carbonyl (PC), and cytokine IL-6 (IL-6) and a significant decrease in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), ferric reducing ability (FRA) and reduced glutathione (GSH) concentrations. α-Lipoic acid supplementation to γ-rays group ameliorates all parameters alteration occurred in blood and rat cardiac tissues, suggesting the existence of a compensatory increase of antioxidant defences. It could be postulated that α-lipoic as a functional dietary supplement could exert a modulator role in the radiation-induced cardiac injury through its antioxidant and anti-inflammatory properties. | ||||
| Keywords | ||||
| α-Lipoic acid; γ-rays; myocardium; rats | ||||
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