Zinc-oxide-silica- nanocomposite: A Sustainable Route to Antimicrobial and Anticancer Application

Farouk, Hanaa Sabra; Elmetwalli, Dr. Alaa; El-Sayyad, Gharieb; O. Abdel Monem, Mohamed.; hassan, jihan; Shahin, Mahmoud S. A; Hassan, Mervat Gameel

doi:10.21608/bjas.2025.370482.1640

	Zinc-oxide-silica- nanocomposite: A Sustainable Route to Antimicrobial and Anticancer Application
Benha Journal of Applied Sciences
Volume 10, Issue 2, February 2025, Page 39-44 PDF (563.99 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2025.370482.1640
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Authors
Hanaa Sabra Farouk ¹; Dr. Alaa Elmetwalli ²; Gharieb El-Sayyad³; Mohamed. O. Abdel Monem⁴; jihan hassan ⁵; Mahmoud S. A Shahin⁶; Mervat Gameel Hassan ⁷
¹Botany and Microbiology Department, Faculty of Science, Benha University, Benha 33516, Egypt
²Sherbin, Mansoura, Egypt
³Drug Radiation Research Department, Egyptian Atomic Energy authority
⁴Professor of Botany and Microbiology Department , Faculty of Science, Benha University
⁵Applied Medical Chemistry Medical Research Institute Alexandria university
⁶Main laboratories for Egyptian Army
⁷Botany and Microbiology Department, Faculty of Science, Benha University, Egypt
Abstract
Background:Zinc oxide silica nanoparticles (ZnO NPs) have drawn interest due to their distinct physical, chemical, and biological characteristics, which make them attractive options for antibacterial and anticancer uses. Hazardous materials are frequently used in traditional chemical synthesis techniques, which makes greener, more sustainable alternatives necessary. Using Alteromonas sp., a bacteria known for its metabolic capabilities, this work investigates the synthesis of ZnO NPs and assesses their characterisation, antimicrobial, and anticancer characteristics.. Methods: (ZnO NPs) were synthesized by incubating Alteromonas sp with zinc acetate and sodium silicate under controlled conditions. The resulting nanoparticles were purified and characterized using UV-Vis, TEM, XRD, DLS, and FTIR. Antimicrobial activity was assessed against bacterial pathogens, while anticancer activity was evaluated using cancer cell lines. Results: The synthesized (ZnO NPs) exhibited significant antimicrobial activity against various pathogens and demonstrated promising anticancer effects by inducing oxidative stress and apoptosis in cancer cell lines. Conclusion: Using Alteromonas sp., the study effectively illustrated a green production method for (ZnO NPs). The identified nanoparticles provided a sustainable substitute for traditional synthesis techniques and demonstrated promise for antibacterial and anticancer uses. To fully investigate their therapeutic potential and methods of action, more research is required.
Keywords
Keywords: Zinc oxide; Silica; Composites; Antibacterial activity


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