A Comprehensive Review on Novasomes As Lipid-Based Drug Carriers | ||
| Sinai International Scientific Journal | ||
| Volume 2, Issue 1, July 2025, Pages 21-35 PDF (738.02 K) | ||
| Document Type: Narrative Review Article | ||
| DOI: 10.21608/sisj.2025.442481 | ||
| Authors | ||
| Yasmin Ismail mortaga* ; Rana E. Elnady | ||
| Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Arish Branch, North Sinai 45511, Egypt | ||
| Abstract | ||
| Background: Novasomes (Novs) are a novel lipid-based drug delivery system (LBDDS) for enhanced drug delivery. Those systems are composed of surface active agents (SAA) and free fatty acids (FFA) that self-assemble into spherical bilayer structures to encapsulate a variety of therapeutic drugs. Novs have been extensively studied as drug carriers, including antifungals, antibiotics, anti- inflammatory, and anticancer drugs. They approved better solubility and permeability, greater therapeutic efficacy, and diminished side effects when compared to free drug formulations. Aims of this review: This review provides a thorough outlook, including novasomal constituents, development techniques, advantages and disadvantages, variant characterizations, routes of administration, pharmacological applications, and future prospects in the field of novasomal research. | ||
| Keywords | ||
| Novs; lipid-based nanocarrier; non-ionic surfactants; permeability | ||
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