Relative miRNA-155-5P Expression and Level of CXCL9, CXCL10 in Patients with Cutaneous leishmaniasis before and after Pentostam Treatment
Aljorany, L., Muhaimid, A., Salih, M. (2026). Relative miRNA-155-5P Expression and Level of CXCL9, CXCL10 in Patients with Cutaneous leishmaniasis before and after Pentostam Treatment. EKB Journal Management System, 35(1), -. doi: 10.21608/ejmm.2025.402847.1771
Lina A. Aljorany; Abdul Khaliq A. Muhaimid; Maan H. Salih. "Relative miRNA-155-5P Expression and Level of CXCL9, CXCL10 in Patients with Cutaneous leishmaniasis before and after Pentostam Treatment". EKB Journal Management System, 35, 1, 2026, -. doi: 10.21608/ejmm.2025.402847.1771
Aljorany, L., Muhaimid, A., Salih, M. (2026). 'Relative miRNA-155-5P Expression and Level of CXCL9, CXCL10 in Patients with Cutaneous leishmaniasis before and after Pentostam Treatment', EKB Journal Management System, 35(1), pp. -. doi: 10.21608/ejmm.2025.402847.1771
Aljorany, L., Muhaimid, A., Salih, M. Relative miRNA-155-5P Expression and Level of CXCL9, CXCL10 in Patients with Cutaneous leishmaniasis before and after Pentostam Treatment. EKB Journal Management System, 2026; 35(1): -. doi: 10.21608/ejmm.2025.402847.1771

Relative miRNA-155-5P Expression and Level of CXCL9, CXCL10 in Patients with Cutaneous leishmaniasis before and after Pentostam Treatment

Egyptian Journal of Medical Microbiology
Article 55, Volume 35, Issue 1, January 2026  XML
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2025.402847.1771
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Authors
Lina A. Aljorany email 1; Abdul Khaliq A. Muhaimid2; Maan H. Salihorcid 2
1College of Dentistry, University of Diyala, Diyala, Iraq
2Department of Biology, College of Science, Tikrit University, Tikrit, Iraq
Abstract
Background: MicroRNAs regulate several immune response pathways in patients with cutaneous leishmaniasis before and after treatment. Objective: The study aimed to estimate the level of immune response before and after treatment with Pentostam by assessing the levels of miRNA-155-5P, CXCL9, CXCL10.  Methodology: This study was conducted on 60 volunteers, 30 with cutaneous leishmaniasis were tested before and after treatment and 30 as a control group. ELISA was performed to determine the level of CXCL9, CXCL10, and the gene expression of miRNA-155-5P was estimated using qRT-PCR. Results: The results of the current study showed a significant increase in relative miRNA-155-5P expression in the control group with patients before treatment (p=0.001) and after treatment(p=0.001). level of CXCL9 was significantly higher in the control group compared to the patient's two groups, p=0.001 and p=0.001, respectively. The level of CXCL10 in the control group increased significantly compared to the patient's groups before treatment (p=0.001) and after treatment (p=0.004). Conclusion: We conclude from the results of the current study that miRNA-155-5P and the immune markers; CXCL9, CXCL10, could constitute a possible therapeutic target or limit the progress of leishmaniasis.
Keywords
miRNAs; cutaneous leishmaniasis; miRNA-155-5P; CXCL9; CXCL10
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