Hematological and antioxidant biomarkers alterations in male albino rats treated with bisphenol A: the protective impact of vitamin E | ||
| Sohag Journal of Sciences | ||
| Volume 10, Issue 3, September 2025, Pages 314-318 PDF (424.41 K) | ||
| Document Type: Regular Articles | ||
| DOI: 10.21608/sjsci.2025.375179.1266 | ||
| Authors | ||
| Amal F. Mahraan; Mohamed F. El-Sayed* ; Tito N. Habib; Mohamed Alaraby | ||
| Zoology Department, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||
| Abstract | ||
| Bisphenol-A (BPA) is one of the most environmental pollutants used as industrial polymers for manufacturing plastics. It causes deleterious effects in humans and animals. Vitamin E is a fat-soluble antioxidant that acts as a reactive oxygen species (ROS) scavenger to prevent lipid peroxidation. The present study was aimed to evaluate the beneficial effect of vitamin E on the hematological and antioxidant biomarkers against the toxicity of bisphenol -A after one month in male albino rats. Twenty -four male albino rats were divided into four groups. The first group acts as a control group, the second group was treated with BPA at 30mg/kg body wt., the third group was treated with Vit. E 160mg/kg body wt., and the fourth group was treated with vitamin E along with BPA. The results obtained revealed that BPA induced remarkable alterations, either increase or decrease in the hematological and antioaxidant biomarkers, with respect to the control. Vitamin E combined with BPA induced a marked enhancement on the toxic effect of BPA on the biomarkers examined. So, it can be concluded that each vitamin E and the combination of vitamin E with BPA have beneficial impact in slightly improved but not completely removing the toxic effects of BPA on the hematological and antioxidant biomarkers as a protective effect preventing the damage of hematopiotic organs and the defense mechanism of antioxidants. | ||
| Keywords | ||
| Bisphenol- A; Vitamin E; hematological parameters; antioxidant biomarkers; albino rats | ||
|
Supplementary Files
|
||
|
Statistics Article View: 108 PDF Download: 79 |
||
