Impact of L-Arginine and Licorice Extract Supplementation on Growth and Epiphyseal Cartilage Health in PCOS-Induced Rats | ||||
| Mansoura Journal of Biology | ||||
| Volume 72, Issue 1, March 2025, Page 50-57 PDF (1005.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjb.2025.442728 | ||||
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| Authors | ||||
| Yasmeen El-Sayed* 1; Heba A. El-Ghaweet1; Abdelaziz Elrefaeey2; Amoura M. Abou-El-Naga1 | ||||
| 1Faculty of Science, Mansoura University, Zoology Department, Mansoura, Egypt. | ||||
| 2Faculty of Medicine, Mansoura University, Obstetrics and Gynecology Department, Mansoura, Egypt. | ||||
| Abstract | ||||
| Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and ovarian dysfunction, often leading to metabolic and reproductive complications. Due to their antioxidant and anti-inflammatory properties, L-arginine and licorice extract have been explored for their potential in infertility management. This study examines the effects of L-arginine and licorice extract on body weight and epiphyseal cartilage morphology in a rat model of PCOS. Forty-eight female rats were divided into six groups (n = 8): Group I (Control) received no treatment; Group II (Licorice) was administered 150 mg/kg licorice extract for 21 days; Group III (L-Arginine) received 3.5 mg/kg L-arginine for 21 days; Group IV (PCOS Model) was induced using 1 mg/kg letrozole for 21 days; Group V (Licorice + PCOS) received licorice extract following PCOS induction; and Group VI (L-Arginine + PCOS) was treated with L-arginine after PCOS induction. The study assessed body weight, absolute weights of the genital system, uterus, and ovaries, along with the histological structure of epiphyseal cartilage. Both L-arginine and licorice extract significantly improved epiphyseal cartilage integrity and regulated body weight, suggesting their potential therapeutic role in PCOS management. | ||||
| Keywords | ||||
| Polycystic Ovary Syndrome; L-arginine; Licorice Extract; epiphyseal cartilage; and Body Weight | ||||
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