An Overview on the Impact of Vitamin C in Attenuating Toxic Effects of Fibronil in Nile Tilapia | ||
| Egyptian Journal of Veterinary Sciences | ||
| Articles in Press, Corrected Proof, Available Online from 20 July 2025 PDF (1.01 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2025.378700.2805 | ||
| Authors | ||
| Sara Ali Gad* 1; Nanies Salim Salim2; Mai Elsyed Nasr3; Sahar Samir Abd EL-Hamied4 | ||
| 1Department of Pathology and Clinical Pathology, Animal Health Research Institute, Zagazig branch, Agricultural Research Center, Egypt. | ||
| 2Biochemistry Department, Animal Health Research Institute, Agricultural Research Centre (ARC), Egypt. | ||
| 3Biochemistry Department, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Egypt. | ||
| 4Pathology and Clinical Pathology Department, Animal Health Research Institute (AHRI), Agricultural Research Centre (ARC), Egypt. | ||
| Abstract | ||
| A two-month experiment was lined up to examine the harmful impacts of Fibronil in Nile Tilapia (Oreochromis niloticus) beside studying the mechanism by which vitamin C can attenuate these effects. One hundred eighty fish were randomly classified into four groups, with three replicates in each (n = 45/group, 15 per replicate). The first group kept as control, the second group was supplemented with vitamin C by (50 mg/L) in water, the third group was exposed to Fibronil by (0.0021 mg/L) (1/20 of 96 hr. LC50) in water, and the fourth group was exhibited to vitamin C and Fibronil together with the same dose of group two and three. There was a significant decrease in BWG and SGR in the fish of group three compared to control and group four. Total RBCs, Hb concentration, and Hct % of Fibronil treated group were significantly decreased than the other groups. The exposure to Fibronil results in a significant elevation of serum levels of ALP, ALT, AST, urea, creatinine, and cortisol with suppression of IgM and lysozyme activity. This toxic effect appeared to be improved by treatment with vitamin C in group (4). Supplementation of vitamin C led to higher Superoxide dismutase (SOD) levels and total antioxidant enzyme capacity. Liver, kidney and intestine of group (3) that treated with Fibronil revealed different histopathological changes which were improved by the addition of vitamin C in group four. Results showed improvement in performance, hematological, biochemical and antioxidant activities by addition of vitamin C. | ||
| Keywords | ||
| Fibronil; Hematology; Immunity; Histopathology; Oreochromis niloticus | ||
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