Measurment of Serum level of Catestatin in patients with Acne vulgaris
kamel, H., Reyad, H., Khattab, O., Naguib, R. (2025). Measurment of Serum level of Catestatin in patients with Acne vulgaris. EKB Journal Management System, 6(3), 48-64. doi: 10.21608/ejmr.2025.368429.1809
Hanan Abdelrazik kamel; Hoda Ramadan Reyad; Omniya Badr Salah Khattab; Rehab Mohamed Naguib. "Measurment of Serum level of Catestatin in patients with Acne vulgaris". EKB Journal Management System, 6, 3, 2025, 48-64. doi: 10.21608/ejmr.2025.368429.1809
kamel, H., Reyad, H., Khattab, O., Naguib, R. (2025). 'Measurment of Serum level of Catestatin in patients with Acne vulgaris', EKB Journal Management System, 6(3), pp. 48-64. doi: 10.21608/ejmr.2025.368429.1809
kamel, H., Reyad, H., Khattab, O., Naguib, R. Measurment of Serum level of Catestatin in patients with Acne vulgaris. EKB Journal Management System, 2025; 6(3): 48-64. doi: 10.21608/ejmr.2025.368429.1809

Measurment of Serum level of Catestatin in patients with Acne vulgaris

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Page 48-64  XML PDF (738.98 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.368429.1809
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Authors
Hanan Abdelrazik kamel1; Hoda Ramadan Reyad2; Omniya Badr Salah Khattab email 3; Rehab Mohamed Naguib1
1Dermatology department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
2Biochemistry department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt
3Dermatology department, Sheikh Zayed Specialized Hospital, Giza12511, Egypt
Abstract
Background: Acne is a persistent inflammatory condition of the pilosebaceous unit. The pathogenesis encompasses three components: hyperseborrhea, aberrant follicular keratinization, and the development of Propionibacterium acnes inside the pilosebaceous unit. Objective: To evaluate serum catestatin (CST) level in Acne vulgaris patients as an attempt to answer the question about its role in disease pathogenesis and severity.  Patients and Methods: This case-control study was carried out on 45 patients with different degrees of acne vulgaris severity (Group A) in addition to 45 age and sex matched healthy volunteers as a control group (Group B).  For all participants, thorough history taking and good general and dermatological examination were done. Serum levels of catestatin were tested. Results: The present investigation revealed that CST levels (ng/ml) in acne vulgaris patients were reported at (8.21±5.70 ng/ml), but in healthy controls, they were (3.04±0.84 ng/ml). A very substantial difference existed between the two groups. Serum levels of CST were somewhat elevated in females relative to men; however, this disparity was statistically insignificant. The levels of CST were elevated in individuals with severe lesions; nevertheless, the serum levels of CST exhibited a non-statistically significant difference concerning lesion severity. There was a significant negative correlation between CST level (ng/ml) and age (years) of the acne patients (r=-0.321, p=0.032). Conclusion: A very substantial difference existed between the two groups regarding CST level but connection to acne severity was not verified.
Keywords
Acne vulgaris; catestatin; severity
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