Efficacy of a herbal-based medication for treatment of paracetamol-induced hepatotoxicity in dogs | ||||
| المجلة العربية للعلوم الزراعية | ||||
| Volume 8, Issue 27, July 2025, Page 159-186 PDF (1020.15 K) | ||||
| Document Type: المقالة الأصلية | ||||
| DOI: 10.21608/asajs.2025.443288 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| I.A. Saleh; M.E. Ali; M.S. Abdulkader; M.M. Zamzamy | ||||
| Department of Medicine and Infectious Diseases , Faculty of Veterinary Medicine , Cairo University, Egypt | ||||
| Abstract | ||||
| This study aimed to evaluate the therapeutic efficacy of a herbal-based formula as an adjunct to silymarin in mitigating paracetamol-induced hepatotoxicity in dogs. Fourteen dogs were experimentally induced with toxicity and divided into two equal groups (n=7). Group 1 (Herbal) was treated with silymarin plus a herbal formula, while Group 2 (Control) received only silymarin. Paracetamol induction caused a significant (P < 0.05) decline in erythrogram parameters (RBCs, HGB, HCT) and a significant elevation in liver enzymes (ALT, AST, ALKP), platelets, total cholesterol, and triglycerides. Treatment with the herbal formula significantly restored hematological values and led to a marked reduction in all elevated biochemical markers, showing superior restorative and hepatoprotective effects compared to the control group. Ultrasonography confirmed a near-complete resolution of hepatic lesions in the herbal-treated group. It is concluded that the tested herbal-based formula is a potent and beneficial adjunctive therapy for accelerating recovery from paracetamol-induced hepatotoxicity in dogs. | ||||
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