Effect of Vitamin D Supplementation on Follicular Fluid BMP-15 and Anti-Müllerian Hormone Production in Average Responder Women Undergoing Intracytoplasmic Sperm Injection | ||||
| Journal of Applied Molecular Biology | ||||
| Volume 3, Issue 2 - Serial Number 2974, July 2025, Page 181-193 PDF (498.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jamb.2025.364101.1043 | ||||
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| Authors | ||||
Radwa A.H. Taha1; Asmaa A. A. Hussein  2; Mohamed Y. Abdelrahman3; Ahmed A. Youssef4
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| 1Department of Molecular Biology, Molecular Biology Research & Studies Institute, Assiut University, Assiut 71511 Egypt, | ||||
| 2Department of Animal Hygiene & Zoonoses Department, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt | ||||
| 3Department of Obstetrics and Gynecology, Faculty of Medicine, Sohag University, Egypt | ||||
| 4Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Assiut 71511Egypt, | ||||
| Abstract | ||||
| AVitamin D (VD) is known to play a crucial role in various physiological processes, including reproductive health. This study investigates the impact of VD supplementation on follicular fluid BMP-15 protein levels and anti-Müllerian hormone (AMH) production in women undergoing Intracytoplasmic Sperm Injection (ICSI). To evaluate the effects of VD supplementation on ovarian reserve markers, and endometrial thickness in women undergoing ICSI. A total of 90 women aged 25-40 years, undergoing ICSI, were enrolled in the study. Participants were divided into a study group receiving VD supplementation and a control group. Baseline characteristics, hormonal profiles, and ovarian reserve markers (AMH and antral follicle count) were assessed. Serum and follicular fluid samples were collected on the day of oocyte retrieval, and VD levels were measured using an ELISA kit. Statistical analyses were performed to compare outcomes between groups. Ninety infertile women undergoing ICSI were allocated to either a control group (n=45) or a study group (n=45). Participants ranged in age from 20 to 40 years, with a mean age of 29.13 ± 3.42 years in the control group and 29.07 ± 2.99 years in the study group. The study found no significant difference in AMH levels between the study group (2.11 ± 0.61 ng/mL) and the control group (2.21 ± 0.61 ng/mL; p = 0.438). VD showed a weak and non-significant correlation with AMH in the study group (r = 0.124, p = 0.418), but a moderate and significant positive correlation in the control group (r = 0.331, p = 0.026). BMP-15 protein levels were weakly correlated with AMH in the study group (r = 0.160, p = 0.294) but showed a significant moderate positive correlation in the control group (r = 0.341, p = 0.022). VD supplementation did not significantly affect AMH levels but was associated with a higher antral follicle count in women undergoing ICSI. These findings suggest that while VD may not influence ovarian reserve as measured by AMH, it could play a role in enhancing follicular development. | ||||
| Keywords | ||||
| Vitamin D; ICSI; Anti-Müllerian Hormone; Follicular Fluid; Ovarian Reserve; Reproductive Health | ||||
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