Genetic Diversity of Interleukin Genes in Egyptian Goat Populations from Different Agro-Climatic Regions and Their Association with Disease Resistance | ||||
| Egyptian Journal of Veterinary Sciences | ||||
| Articles in Press, Corrected Proof, Available Online from 22 July 2025 PDF (731.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejvs.2025.382499.2831 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sahar A. El Nahta   1; Sonia S Kropff2; Reda Ismail Elsayed3; Neama Ibrahim ALI3; Antoinette Kotzé4
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| 1Cell Biology Department, National Research Centre, Giza, Egypt. | ||||
| 2South African National Biodiversity Institute, P.O. Box 754, Pretoria, 0001, South Africa | ||||
| 3Department of Cell Biology, Biotechnology Research Institute, National Research Centre, Giza, Egypt | ||||
| 4Department of Genetics, University of the Free State, P.O. Box 339, Bloemfontein, 9300 South Africa | ||||
| Abstract | ||||
| Environmental stressor factors play an important role in shaping genetic diversity. The study aimed to assess the genetic diversity of IL genes and their association with disease resistance in six Egyptian goat populations. Blood samples were collected from six distinct goat populations to extract DNA. Data on of infectious diseases in animals were collected from owners. Polymerase chain reaction (PCR) amplification, sequencing, and bioinformatic analyses were conducted on four genes belonging to the IL family. The results revealed that the Interleukin 4 (IL4 exon3) gene was conserved among the Egyptian goat populations. While three haplotypes were observed for the Interleukin IL2 (exons 1 and 2) genes across the six breeds, 8 haplotypes were detected for IL2 (exon 3) and 4 haplotypes for Interleukin 13 (exon 4) genes. The phylogeny of Egyptian goat IL genes revealed more informative data for determining genetic distances between the populations. Based on the different genotypes of the studied IL genes and their association with the diseases in goats, the results suggested that the Hape_1 and Hap_3 of IL2 (exons 1 and 2) could be considered as candidate molecular markers for selecting goats with disease resistance in Aswani and Saedi and in Baladi, Barki, Sharkawi, and Zaribi, respectively. In conclusion, the results of the genetic analysis showed diversity of the IL genes among the Egyptian goat populations that may be associated with adaptation of each population to a specific environmental stress, including possible disease resistance. | ||||
| Keywords | ||||
| Interleukin genes; Goat breeds; genetic variation; agro-climates; innate immune | ||||
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