Chicken's Egg Model is A Hope for Tumor Research.
El-Komy, E., Tawfik, M., Ewies, E. (2025). Chicken's Egg Model is A Hope for Tumor Research.. EKB Journal Management System, (), -. doi: 10.21608/ejchem.2025.382793.11727
Esteftah Mohamed El-Komy; Mariam Sherif Tawfik; Ewies F. Ewies. "Chicken's Egg Model is A Hope for Tumor Research.". EKB Journal Management System, , , 2025, -. doi: 10.21608/ejchem.2025.382793.11727
El-Komy, E., Tawfik, M., Ewies, E. (2025). 'Chicken's Egg Model is A Hope for Tumor Research.', EKB Journal Management System, (), pp. -. doi: 10.21608/ejchem.2025.382793.11727
El-Komy, E., Tawfik, M., Ewies, E. Chicken's Egg Model is A Hope for Tumor Research.. EKB Journal Management System, 2025; (): -. doi: 10.21608/ejchem.2025.382793.11727

Chicken's Egg Model is A Hope for Tumor Research.

Egyptian Journal of Chemistry
Articles in Press, Accepted Manuscript, Available Online from 22 July 2025  XML
Document Type: Review Articles
DOI: 10.21608/ejchem.2025.382793.11727
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Authors
Esteftah Mohamed El-Komy1; Mariam Sherif Tawfik2; Ewies F. Ewies email orcid 3
1Department of Animal Production, National Research Centre, 33 ElBohouth St., (Former El Tahrir) Dokki, P.O. 12622, Giza, Egypt
2College of Biotechnology, Misr University for Science and Technology (MUST), Al Motamayez District – 6th of October, Giza, Egypt
3Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 ElBohouth St., (Former El Tahrir) Dokki, P.O. 12622, Giza, Egypt
Abstract
The complexity of tumor biology and the urgent need for effective therapeutic strategies have driven the exploration of novel in vivo models. The chicken egg chorioallantoic membrane (CAM) model has emerged as a powerful, cost-effective, and ethically favorable tool in cancer research. Leveraging its immune-deficient window and high vascularity, the CAM model supports xenotransplantation of human tumor cells and patient-derived tissues, enabling real-time monitoring of tumor growth, angiogenesis, metastasis, and therapeutic responses. This review highlights the historical development, biological underpinnings, technical methodologies, and modern applications of the CAM model in oncology. Particular emphasis is placed on its utility in studying gliomas, renal and laryngeal carcinomas, and other solid tumors, as well as its role in photodynamic therapy and biomaterials research. Despite certain limitations, the CAM assay presents a promising alternative to rodent models and serves as a bridge between in vitro experimentation and mammalian preclinical trials
Keywords
tumor biology; CAM model, historical development, biological underpinnings, technical methodologies
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