EXPRESSION OF GLYCOGEN SYNTHASE KINASE 3 BETA IN PATIENT OF PSORIASIS
Abdellatif, M., Mahmoud, L., Rashed, L., El-Rifaie, A. (2025). EXPRESSION OF GLYCOGEN SYNTHASE KINASE 3 BETA IN PATIENT OF PSORIASIS. EKB Journal Management System, 6(3), 119-131. doi: 10.21608/ejmr.2021.93612.1122
Mona El Sayed Abdellatif; Lamis Ahmed Mahmoud; Laila Ahmed Rashed; Abd-El Aziz El-Rifaie. "EXPRESSION OF GLYCOGEN SYNTHASE KINASE 3 BETA IN PATIENT OF PSORIASIS". EKB Journal Management System, 6, 3, 2025, 119-131. doi: 10.21608/ejmr.2021.93612.1122
Abdellatif, M., Mahmoud, L., Rashed, L., El-Rifaie, A. (2025). 'EXPRESSION OF GLYCOGEN SYNTHASE KINASE 3 BETA IN PATIENT OF PSORIASIS', EKB Journal Management System, 6(3), pp. 119-131. doi: 10.21608/ejmr.2021.93612.1122
Abdellatif, M., Mahmoud, L., Rashed, L., El-Rifaie, A. EXPRESSION OF GLYCOGEN SYNTHASE KINASE 3 BETA IN PATIENT OF PSORIASIS. EKB Journal Management System, 2025; 6(3): 119-131. doi: 10.21608/ejmr.2021.93612.1122

EXPRESSION OF GLYCOGEN SYNTHASE KINASE 3 BETA IN PATIENT OF PSORIASIS

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Pages 119-131    PDF (495.45 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2021.93612.1122
Authors
Mona El Sayed Abdellatif1; Lamis Ahmed Mahmoud* 2; Laila Ahmed Rashed3; Abd-El Aziz El-Rifaie1
1Dermatology and Venereology department, Faculty of Medicine, Beni-Suef University, Egypt
2Dermatology and Venereology department, Beni-Suef, Egypt
3Biochemistry department, Faculty of Medicine, Cairo University, Egypt
Abstract
The objective of the present investigation was to identify a correlation between GSK3β and the pathogenesis of psoriasis using PCR. A Case-Control research was undertaken from February 2019 to February 2020 at the Dermatology outpatient clinic of Beni-Suef University Hospital. This research included 30 patients with persistent plaque psoriasis and 30 age- and sex-matched healthy controls. Skin biopsies were obtained from all participants in the research (psoriasis sufferers and healthy controls) to examine the expression of GSK-3β. The expression of GSK-3β was markedly elevated in psoriasis skin lesions compared to healthy control skin (5.61 vs. 1.03; p-value <0.001). The expression of GSK3β was marginally elevated in male psoriasis patients relative to females, albeit this difference was not statistically significant (p-value = 0.674).There were non-statistically significant association of (GSK-3β) expression with disease onset, disease course and family history. Patients’ age was moderately negative correlated with (GSK-3β) expression; (r= -0.471, p= 0.009). The PASI score was strongly positive correlated with (GSK-3β) expression (r= 0.776, p<0.001). There may be roles of up-regulated (GSK-3β) in lesional skin of psoriasis patients as compared with healthy controls. Nonetheless, an additional gain-of-function or loss-of-function experiment may be beneficial to clarify the involvement of GSK-3β in psoriatic skin lesions
 
Keywords
Psoriasis; GSK-3β; PCR
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