Evaluating the effect of bleomycin injection in the head and neck hemangiomas and different types of low flow vascular malformation: cohort retrospective study

Atteya, Aly Mohamed Ahmed; Abd ElHamid, Mariam Mariam A. R.; Gad, Gamal Ali Swaify; Koraitim, Mohamed M.; Abdou, Ahmed S. M.

doi:10.21608/omx.2025.392189.1291

	Evaluating the effect of bleomycin injection in the head and neck hemangiomas and different types of low flow vascular malformation: cohort retrospective study
Egyptian Journal of Oral and Maxillofacial Surgery
Volume 16, Issue 3, July 2025, Page 98-107 PDF (1.47 MB)
Document Type: Original Article
DOI: 10.21608/omx.2025.392189.1291
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Authors
Aly Mohamed Ahmed Atteya ¹; Mariam Mariam A. R. Abd ElHamid²; Gamal Ali Swaify Gad²; Mohamed M. Koraitim²; Ahmed S. M. Abdou²
¹Cranio-Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
²Cranio-Maxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Abstract
Introduction: Vascular anomalies are considered the most common form of congenital and neonatal dysmorphogenesis. They are classified into hemangiomas and vascular malformations (VMs) which are divided into high and low flow VMs which include venous, lymphatic, and combined lymphatico- venous malformations. Different treatment modalities for vascular anomalies including sclerotherapy, vessel embolization, surgical excision and a conjunction of these. Bleomycin developed as a cytotoxic antitumor agent Which has an antiproliferative effect. It has been become widely used for treatment of vascular anomalies because of its high sclerosing effect on vascular endothelium. Objective: to evaluate clinical and radiological effect of bleomycin injection for the treatment of head & neck hemangioma & different types of low flow vascular malformation. Materials and Methods: a retrospective study was done on 25 patients with different types of vascular anomalies and were treated by intralesional bleomycin injection at the Department craniomaxillofacial & plastic surgery at Alexandria university & Nile of hope hospital. Results: The clinical, radiographical and patient satisfaction outcomes were markedly improved. Conclusions: bleomycin injection into vascular lesion is a noninvasive modality for vascular malformations treatment with excellent results and low cost.
Keywords
Bleomycin injection; Low flow vascular malformation; Hemangioma; Head and neck


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