The role of Zingiber officinale in alleviating brodifacoum-induced toxicity in male Mus musculus

Fawzy Gaafer, Amr Mohamed; rady, gad hamada; mohamed, ghada refaat; asran, abdulmawgoud abdalla; elbath, moamen Ahmed

doi:10.21608/bjas.2025.365685.1608

	The role of Zingiber officinale in alleviating brodifacoum-induced toxicity in male Mus musculus
Benha Journal of Applied Sciences
Volume 10, Issue 3, March 2025, Page 47-55 PDF (578.27 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2025.365685.1608
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Authors
Amr Mohamed Fawzy Gaafer ¹; gad hamada rady²; ghada refaat mohamed²; abdulmawgoud abdalla asran¹; moamen Ahmed elbath²
¹Plant Protection Research institute, Dokki, Giza. Egypt
²Plant Protection Department, Faculty of Agriculture, Banha University.
Abstract
In the present study focuses on examining the effects of brodifacoum on chromosomal structure and the histopathological changes in the liver and testis of male mice, as well as the protective role of ginger extract. A total of 130 adult albino male mice were involved in the study. Group a (G1) was the control, while groups b and c (G2 and G3) received ginger extract at doses of 1.5% and 3%. Groups d and e (G4 and G5) were given a single dose of brodifacoum, with G4 receiving 1/10 of the lethal dose (LD50) and G5 receiving 1/20 of the LD50. Groups f through i were treated with brodifacoum followed by ginger extract, while groups j through k received ginger extract first, then brodifacoum. Afterward, the mice were sacrificed, and their bone marrow cells were analyzed for chromosomal damage. Liver and testis samples were collected for histopathological evaluation. The group treated with brodifacoum showed a significant increase in chromosomal abnormalities and a reduction in the mitotic index. Additionally, histological changes were observed in the liver and testis. However, in mice treated with both brodifacoum and ginger, chromosomal aberrations decreased, the mitotic index increased, and there were slight improvements in liver and testis histology. These findings suggest that brodifacoum has mutagenic effects on chromosomes and causes histopathological changes in organs like the liver and testis, while ginger may serve as a protective agent against the toxic effects of brodifacoum.
Keywords
Brodifacoum; Anticoagulant Rodenticides; Chromosomal Aberrations


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