Trichinella spiralis infection: An insightful study | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 22 July 2025 | ||
| Document Type: Review Article | ||
| DOI: 10.21608/mid.2025.398240.2953 | ||
| Authors | ||
| Ghada M Fathy; Samira M. Metwally; Asmaa El-taib Zain El-dein; Marwa Omar* | ||
| Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, 44511, Egypt | ||
| Abstract | ||
| Background: Trichinosisis a food borne zoonotic disease caused by parasitic nematode species belonging to the genus Trichinella. Trichinella spiralis (T. spiralis) is the most virulent pathogenic species affecting humans. Human hosts acquire the infection through ingestion of raw or insufficiently cooked meat of pigs or other animal hosts containing Trichinella spiralis encysted larvae. Following ingestion of the infected meat, larvae are released upon gastric digestion in the new host, and the first-stage larval parasites reach the intestinal tract and develop into adult worms. After mating, adult females shed larvae that migrate to other organs through vascular system. The developing larvae invade skeletal muscles forming nurse cell complexes. In addition to the importance of trichinosis as a cause of morbidity and mortality, it is also regarded as a cause of income loss for farmers and meat processors. Therefore, trichinosis is a concern for public health authorities worldwide. To establish effective prevention and control programmes, awareness of the complex morphology and biology of trichinosis must be increased. Hence, this article aims to provide updated insights into the morphological, pathological and diagnostic aspects of Trichinella spiralis infection. | ||
| Keywords | ||
| Keywords: Trichinella spiralis; pathology; trichinosis; immune response | ||
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