ASSESSMENT OF ROLE OF EMPAGLIFLOZIN, ROYAL JELLY AND HYDROXYCHLOROQUINE IN PREVENTION OF ACUTE GENTAMYCIN INDUCED NEPHROTOXICITY IN ALBINO RATS | ||||
| The Egyptian Journal of Forensic Sciences and Applied Toxicology | ||||
| Volume 25, Issue 2, June 2025, Page 63-77 PDF (1.12 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejfsat.2025.386940.1375 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ezzeldin Shalaby   ; Marwa Abdel Nasser Mohamed; Karima Mokhtar Mohamed ahmed; Nermin Nabil Fayed
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| Al kasr Alani street | ||||
| Abstract | ||||
| Abstract:- Background: Gentamycin is aminoglycoside antibiotic which has potent bactericidal activities, less bacterial resistance, post-antibiotic effects and low cost but its uses limited due to nephrotoxicity. The Reno-protective effects of new sodium-glucose cotransporter 2 inhibitor drug Empagliflozin has been studied in Acute Kidney Injury and in some drugs induced nephrotoxicity. Protective effect of royal jelly was studied in many drug nephrotoxicity. Hydroxychloroquine antimalarial drug has potential protective mechanisms in kidney especially from toxins. Aim: we aimed in the present study to assess role of Empagliflozin, Royal jelly and Hydroxychloroquine in prevention of acute gentamycin induced nephrotoxicity in albino rats. Methods: In the present study, 25 male Wistar albino rats used in our study divided into 5 groups each group 5 rats: Group A control group. Then the four other groups received gentamycin SC 100 mg/kg/day for seven consecutive days to induce Nephrotoxicity, Group B gentamycin alone, Group C received Gentamicin + oral Royal Jelly 100 mg/kg for 7 days. Group D received Gentamicin + oral Empagliflozin 30 mg/kg/day for 7 days and Group E received Gentamicin + Hydroxychloroquine 1mg /kg/day for 7 days, We drew blood sample from all rats for Urea and Creatinine, on day 8, in addition to kidneys histopathology of sacrificed rats. Result: In the present study, Hydroxychloroquine followed by Empagliflozin show significant Reno-protection but Royal Jelly show mild Reno-protection against Gentamycin induced acute nephrotoxicity in both laboratory and histopathological results. Conclusion: Hydroxychloroquine and Empagliflozin | ||||
| Keywords | ||||
| Gentamycin; Empagliflozin; Royal jelly; Hydroxychloroquine; Nephrotoxicity | ||||
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