Toxic Effect of Deltamethrin on the Sciatic Nerve and the Ameliorative Effect of Ginseng in Adult Male Albino Rat (Ultrastructure and Morphometric Study) | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 23 July 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.390782.3981 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Magdy M El Fark   1; Omayma M Mahmoud2; Sahar Khalil3; Nermine S. Ahmed Nosseir4
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| 1Assistant professor of Human Anatomy and Embryology, Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||||
| 2Professor of Human Anatomy and Embryology, Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. | ||||
| 3Professor of Histology and Cell Biology, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | ||||
| 4Assistant Professor of Human Anatomy and Embryology, Department of Human Anatomy and Embryology, College of Medicine, Gulf Medical University, UAE | ||||
| Abstract | ||||
| Background: Ginseng enhances defense against harmful influences and restoration of homeostasis. Its active components are beneficial for treating neurodegeneration. Aim: The present study aimed to investigate the potential protective impact of ginseng on sciatic nerve neuropathy caused by deltamethrin. Methods: Rats were sacrificed twenty-four hours following their previous deltamethrin dose. Light and electron microscopy, as well as morphometric examinations, were conducted on samples collected from the right sciatic nerve. Results: Light microscopy and morphometric studies of the deltamethrin treated group showed a significant decrease in myelin fiber diameter, thickness, and number of myelin fibers, and a non-significant decrease in axon diameter. The co-administration of ginseng with deltamethrin showed a statistically nonsignificant increase in myelin fiber diameter, thickness, number of myelin fibers, and axon diameter compared to the deltamethrin group. The ultrastructural examination of the deltamethrin group showed extensive axonal degeneration and atrophy. Disrupted and separated myelin sheaths with dilated Schmidt-Lanterman clefts were seen. Axonal “Onion bulb" appears in some of the nerve fibers with edema of the unmyelinated nerve fiber. Edematous Schwann cell with vacuolation, and endoneurium edema. Swelling, disrupted cisterna, and vacuolation of axonal mitochondria were noticed. The co-administration of ginseng with deltamethrin is considered a promising therapeutic factor in nerve repair and regeneration. Conclusion: Ginseng is useful for regenerating the sciatic nerve after deltamethrin's damaging effects. | ||||
| Keywords | ||||
| Keywords: Pyrethroid; deltamethrin; ginseng; Sciatic nerve injury; rat | ||||
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