Interleukin 1 Beta Gene Variants in Neonatal Sepsis | ||||
| Benha Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 23 July 2025 PDF (414.79 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2025.375488.2367 | ||||
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| Authors | ||||
Rasha M. Zakaria1; Adel S. El Sayed2; Omima M. Abdel haie2; Shuzan M. Ali3; Noha G. Seyam  4
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| 1Lecturer of Pediatrics, Faculty of Medicine, Benha University | ||||
| 2Professor of Pediatrics, Faculty of Medicine, Benha University | ||||
| 3Professor of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University | ||||
| 4(MSc. Faculty of Medicine, Benha University) | ||||
| Abstract | ||||
| Background: Neonatal sepsis is a leading cause of morbidity and mortality in neonatal intensive care units (NICUs). Genetic variations, particularly in the Interleukin-1 beta (IL-1β) gene, have been implicated in sepsis susceptibility. This study investigates the association of IL-1β polymorphisms (rs16944 and rs1143643) with neonatal sepsis and its clinical outcomes. Methods: A case-control study was conducted on 200 neonates (100 with sepsis and 100 healthy controls) admitted to the NICUs of Benha University Hospitals and Benha Children’s Hospital. Demographic, clinical, and laboratory data were collected. IL-1β polymorphisms were analyzed using real-time PCR. Results: The neonatal sepsis group had higher heart rate (146 ± 28 bpm vs. 121 ± 12 bpm; P < 0.001) and respiratory rate (54 ± 11 vs. 51 ± 5; P = 0.002), and lower blood pressures (P < 0.001). The IL-1β rs16944 AA genotype was more frequent in the sepsis group (26% vs. 15%; OR 2.9, P = 0.023), and the rs1143643 TT genotype (19% vs. 9%; OR 2.4, P = 0.033). The GG genotype of rs16944 was associated with reduced mechanical ventilation (9.5% vs. 43%; P = 0.005) and higher hemoglobin (P = 0.034). Conclusion: IL-1β gene polymorphisms, particularly rs16944 and rs1143643, may play a role in neonatal sepsis susceptibility and clinical outcomes. | ||||
| Keywords | ||||
| Neonatal Sepsis; IL-1β Polymorphisms; Rs16944; Rs1143643; Genetic Susceptibility | ||||
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