Association between estimated urinary and serum sodium-to-potassium ratios and blood pressure in systemic lupus erythematosus patients with hypertension | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 July 2025 PDF (611.82 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.377621.2376 | ||
| Authors | ||
| Doaa Hosny Mahran* 1; Sahar S Ganeb2; Jehan H. Sabry3; Mohamed Khater4; Noha Maher Abdelnaser5 | ||
| 1Rheumatology Rehabilitation and physical medicine , faculty of medicine , banha university | ||
| 2Professor of Rheumatology, Rehabilitation and Physical Medicine . Faculty of Medicine – Banha University. | ||
| 3professor of Clinical and Chemical Pathology Faculty of Medicine – Banha University. | ||
| 4Lecturer of Cardiology Faculty of medicine – Banha University | ||
| 5Assistant Professor of Rheumatology, Rehabilitation and Physical medicine Faculty of medicine-Benha University . | ||
| Abstract | ||
| Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder affecting multiple organs, including kidneys and cardiovascular system. Electrolyte disturbances, especially the sodium -to-potassium (Na-to-K) ratios, are gaining attention as indicators of disease activity and cardiovascular risk in SLE individuals. However, there is a lack of extensive research on the connection between Na-to-K ratios, disease activity, and hypertension(HTN) in SLE. Objectives: This study researched the association between urinary and serum Na-to-K ratios, blood pressure, and disease activity in SLE cases with HTN. Methodology: A case-control analysis was performed on SLE cases with HTN, evaluating demographic, clinical, laboratory, and echocardiographic parameters. Multiple regression and logistic regression analyses were done to identify independent predictors of disease activity and cardiovascular risk. Results: The study detected a significant association between urinary Na-to-K ratio and disease activity, as measured by SLE Disease Activity Index, C-reactive protein, and erythrocyte sedimentation rate, with no significant association between serum Na-to-K ratio and disease activity. Elevated urinary Na-to-K ratio correlated with elevated inflammation and disease activity. Additionally, HTN was more prevalent in cases with elevated urinary Na-to-K ratios, indicating a possible link between electrolyte imbalance and cardiovascular complications in SLE. Conclusion: The urinary Na-to-K ratio could potentially act as a non-invasive biomarker for tracking disease activity and assessing cardiovascular risk in SLE. Future longitudinal and multi-center investigations are recommended to further validate these associations and explore potential interventional strategies targeting electrolyte balance in SLE management. Key words: SLE ; Sodium to Potassium ratio SLEDAI ; HTN. | ||
| Keywords | ||
| SLE; Sodium to Potassium ratio SLEDAI; HTN | ||
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