Possible cardiac benefits of combination of oral semaglutide and empagliflozin in treatment of type2 diabetic rats | ||
| Benha Medical Journal | ||
| Articles in Press, Accepted Manuscript, Available Online from 23 July 2025 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2025.394075.2470 | ||
| Authors | ||
| Heba A. El Noury1; Ahmed F. Bahriz1; Omaima M. Abdallah2; Fatma A. Elsayed* 3; Eman A. Elgebaly4 | ||
| 1Department of Clinical Pharmacology Faculty of medicine, Benha university | ||
| 2Department and head of Clinical Pharmacology, Faculty of medicine, Benha university | ||
| 3Department of Clinical Pharmacology, Faculty of medicine, Benha university | ||
| 4Department of Clinical Pharmacology, Faculty of Medicine, Benha university | ||
| Abstract | ||
| Background: Throughout the last thirty years, the occurrence of diabetes has significantly risen in low- and middle-income countries. Diabetes is associated with both micro- and macrovascular complications. For numerous people with type 2 diabetes, the use several glucose-lowering treatments can be necessary to attain good glycemic control. Oral semaglutide is the 1st GLP-1RA accessible in tablet form, potentially enhancing management intensification had GLP-1RAs and giving an alternative for cases who prefer oral glucose-lowering treatment to attain superior glycemic control. Empagliflozin, a selective sodium-glucose cotransporter 2 inhibitor (SGLT2I), decreases hyperglycemia in cases had type 2 diabetes mellitus by diminishing renal glucose reabsorption and rising urinary glucose excretion. Aim of the study: The objective of the present research is to evaluate the possible benefits of the combination of oral empagliflozin and semaglutide in the management of type 2 diabetic rats and some of its associated CVS complications. Methods: Rats have been categorized into: Group 1: control normal group. Group 2: wasn’t managed diabetic (diseased group). Group 3: was managed with oral semaglutide. Group 4: was managed with empagliflozin. Group 5: was managed with oral semaglutide and empagliflozin. Treated groups received medications for four weeks. Results: Treated groups illustrated significant enhancement in almost all measured variables and the histopathology of the myocardium at the end of the fourth week of treatment. Conclusion: Our research demonstrated that the combined treatment by oral semaglutide and empagliflozin was superior to each drug alone in improving all parameters. | ||
| Keywords | ||
| diabetes mellitus; micro- and macrovascular complications; oral semaglutide; empagliflozin | ||
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