SAFETY AND EFFICACY OF STEM CELL FORTIFIED EYE DROPS IN CORNEAL ULCER TREATMENT
P., S., M., S., W., A., Sh., A., A., A., A., S., W., M. (2025). SAFETY AND EFFICACY OF STEM CELL FORTIFIED EYE DROPS IN CORNEAL ULCER TREATMENT. EKB Journal Management System, 8(1), 51-58. doi: 10.21608/ejco.2025.443639
Saif, P.; Saif, M.; Amoako, W.; Amer, Sh.; Abdelkarim, A.; Saif, A.; Mahran, W.. "SAFETY AND EFFICACY OF STEM CELL FORTIFIED EYE DROPS IN CORNEAL ULCER TREATMENT". EKB Journal Management System, 8, 1, 2025, 51-58. doi: 10.21608/ejco.2025.443639
P., S., M., S., W., A., Sh., A., A., A., A., S., W., M. (2025). 'SAFETY AND EFFICACY OF STEM CELL FORTIFIED EYE DROPS IN CORNEAL ULCER TREATMENT', EKB Journal Management System, 8(1), pp. 51-58. doi: 10.21608/ejco.2025.443639
P., S., M., S., W., A., Sh., A., A., A., A., S., W., M. SAFETY AND EFFICACY OF STEM CELL FORTIFIED EYE DROPS IN CORNEAL ULCER TREATMENT. EKB Journal Management System, 2025; 8(1): 51-58. doi: 10.21608/ejco.2025.443639

SAFETY AND EFFICACY OF STEM CELL FORTIFIED EYE DROPS IN CORNEAL ULCER TREATMENT

Egyptian Journal of Clinical Ophthalmology
Article 7, Volume 8, Issue 1, June 2025, Page 51-58  XML PDF (406.06 K)
Document Type: Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations
DOI: 10.21608/ejco.2025.443639
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Authors
Saif, P.1; Saif, M.2; Amoako, W.3; Amer, Sh.4; Abdelkarim, A.5; Saif, A.6; Mahran, W.7
1Ophthalmology dept., Misr Univ. for Science and Technology, 6th October, Egypt,
2Ophthalmology dept., Beni-Suef Univ., Beni-Suef, Egypt, Niles Institute of Longevity Elder Sciences, Beni-Suef Univ., Beni-Suef, Egypt,
3European Wellness Academy, Kota Kinabalu – Malaysia,
4British Center for Regenerative Medicine, Cairo, Egypt,
5British Center for Regenerative Medicine, Cairo, Egypt, ACE Cells Lab, UK,
6Ophthalmology dept., Fayoum Univ., Fayoum, Egypt
7Ophthalmology dept., Beni-Suef Univ., Beni-Suef, Egypt,
Abstract
Purpose: To evaluate the therapeutic efficacy of stem cell-derived Fortified Drops (ACE Orbit™) in managing persistent and regular corneal ulcers unresponsive to conventional treatment. Methods: This prospective, interventional study included 33 eyes—10 with persistent ulcers (>2 weeks) and 23 with regular ulcers (<2 weeks)—treated with bioactive peptide-based Fortified Drops thrice daily for 30 days. Clinical assessments included epithelial closure, visual acuity, corneal clarity via OCT, pachymetry, and levels of inflammatory biomarkers (MMP-9 and IL-1β). Results: Complete epithelial healing occurred in 80% of persistent ulcers and 100% of regular ulcers (p= 0.009). Group 2 exhibited significantly better outcomes in corneal clarity (p < 0.001), faster healing (15.2 ± 3.2 vs. 22.5 ± 4.5 days, p < 0.001), and greater reductions in MMP-9 and IL-1β levels (p= 0.045 and p=0.027, respectively). Visual acuity and central corneal thickness improved in both groups, though not statistically significantly between them. Mild irritation was the only common adverse effect; one case of perforation occurred in Group 1. Conclusion: Fortified Drops sign-ificantly enhanced corneal healing, reduced inflammation, and improved corneal clarity, particularly in regular ulcers. Although persistent ulcers showed slower and less complete healing, the drops demonstrated promising regenerative potential and a favorable safety profile. These findings support the use of Fortified Drops as a non-invasive, adjunctive treatment for challenging corneal ulcer cases.
Keywords
Corneal ulcers; Stem cell; Fortified eye
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