Cirrhotic cardiomyopathy: Correlation with hepatic decompensation severity and hepatorenal syndrome | ||
| Medical Journal of Viral Hepatitis | ||
| Article 5, Volume 9.1, Issue 1, March 2025, Pages 29-36 PDF (513.54 K) | ||
| Document Type: Original article | ||
| DOI: 10.21608/mjvh.2025.443643 | ||
| Authors | ||
| Eman helal* 1; Nouran Mansour2; Sally Gamaleldin3; Kariman Elkasrawy1 | ||
| 1Tropical Medicine and Infectious Diseases dept., Faculty of Medicine, Tanta Univ., Tanta, Egypt. | ||
| 2Cardiology dept., Faculty of Medicine, Tanta Univ., Tanta, Egypt. | ||
| 3Internal Medicine and Nephrology dept., Faculty of Medicine, Tanta University, Tanta, Egypt. | ||
| Abstract | ||
| Background and study aim: Cirrhotic cardiomyopathy is a cardiac dysfunction that can occur in patients with cirrhosis, independent of other heart conditions. It is linked to the severity of liver disease, portosystemic shunt, and portal hypertension in cirrhosis. Hepatorenal syndrome is directly linked to inad-equate cardiac output and circulatory dysfunction. Evaluating subclinical cardiac involvement is crucial for optimizing tre-atment follow-up. Our study aimed to explore the connection between cirrhotic cardiomyopathy, the severity of liver disease, and complications particularly hepatorenal syndrome. Patient and methods: Sixty cirrhotic patients, matched for sex and age, were selected for the study and divided into three groups. The first group consisted of twenty patients with Child score A, the second group included twenty patients with Child scores B and C, and the third group comprised 20 decompensated cirrhotic patients complicated with HRS. All patients underwent cardiac function assessment through ECG and Doppler study. Cirrhotic cardiomyopathy was dia-gnosed based on the 2019 criteria, which included systolic dysfunction (left ventricle ejection fraction < 50%) and diastolic dysfunction (meeting at least three of the following criteria: 1. Septal e′ velocity < 7 cm/s, 2. E/e′ ratio ≥ 15, 3. Tricuspid regurgitation velocity > 2.8 m/second, 4. left atrium volume index (LAVI) > 34 mL/m2). Results and conclusions: The study showed that 14 out of 60 patients (23.33%) exhibited diastolic dysfunction: none in group I, five in group II, and nine in group III. Patients with cirrhotic cardiomyopathy had higher Child scores (p < 0.001), serum creatinine levels, and presence of HRS (p=0.009 for both) compared to those without cirrhotic cardiomyopathy. A strong positive correlation between Child score and corrected QT interval (p < 0.001, r=0.838) was observed. Conclusion: Cirrhotic cardiom-yopathy is prevalent in a significant number of cirrhotic patients and is linked to the severity of liver disease as indicated by the Child-Pugh score and the occurrence of complications particularly hepatorenal syndrome. | ||
| Keywords | ||
| CCM; decompensated cirrhosis; HRS | ||
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