Antimicrobial resistance patterns among ESBL Klebsiella pneumoniae isolated from different clinical samples in Baghdad City, Iraqi | ||||
| Microbes and Infectious Diseases | ||||
| Articles in Press, Accepted Manuscript, Available Online from 24 July 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mid.2025.400826.2991 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mustafa Mahmoud Al-Qaisi  ; Raghad Hassan Hussein ; Luma Yousif Mahdi
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| Department of Medical Laboratory Techniques, College of Health and Medical Techniques, Middle Technical University, Baghdad, Iraq | ||||
| Abstract | ||||
| Background: Multidrug-resistant (MDR) trait among extended-spectrum-β-lactamases (ESBL) producing Klebsiella pneumoniae (K. pneumoniae) has recently developed resulting in difficulties in treating infections. To overcome the spread of these K. pneumoniae isolates and decrease their pathogenesis, it is crucial to investigate the antibiotic resistance pattern among them. This study aims to exhibit the effect of ESBL-producing K. pneumoniae on antibiotic resistance in different clinical infections among Iraqi patients. Methods: A total 100 K. pneumoniae isolates were isolated from various clinical samples, in Baghdad city, Iraq. These isolates were subjected to microbiological identification analyses, chromogenic medium, and VITEK2 system. K. pneumoniae isolates were phenotypically screened for ESBL production among and their antibiotic resistance against several antibiotic classes was examined. Results: Of the 100 isolates, 69% were ESBL-producing K. pneumoniae. Among them, 32/69 (46.4%) were recorded as being XDR, furthermore, the interesting findings was that PDR pattern was found in 12/69 (17.4%) of ESBL-producing isolates. Conclusion: The study confirmed the role of ESBL production feature in developing high levels of antimicrobial resistance patterns among clinically isolated Klebsiella pneumoniae. | ||||
| Keywords | ||||
| Klebsiella pneumoniae; ESBL Production; Antimicrobial Resistance Pattern; MDR | ||||
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