Histological Study of the Possible Protective Effect of Lycopene on Ethanol Induced Gastritis in Adult Male Albino Rats | ||||
| Zagazig University Medical Journal | ||||
| Volume 31, Issue 8, August 2025, Page 4139-4151 PDF (1.84 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.398057.4023 | ||||
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| Authors | ||||
Nehal Farid El-Helbawy1; Suzan Elsayed Abo Elnasr   2
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| 1Anatomy and Embryology, Faculty of Medicine, Tanta University | ||||
| 2Department of Histology and cell biology, Faculty of medicine, Tanta University | ||||
| Abstract | ||||
| Background: Gastritis is the inflammation of gastric mucosa which is diagnosed by its abnormal appearance on endoscopy or radiology. Lycopene has beneficial preventive properties against neurological and cardiovascular disorders, so this work aimed to evaluate the protective effect of lycopene on ethanol induced gastritis in adult male albino rats. Methods: This experiment included 32 adult male albino rats split into four groups: Group I was the control group. Group II (Lycopene group): For three weeks, each rat was given 5 mg/kg of lycopene dissolved in corn oil orally every day. Group III (Ethanol group): All rats were given free access to water and fasted for the whole night. In order to cause gastritis, a single dosage of 5 ml/kg of 100% ethanol was given to fasted rats. Group IV (Ethanol + Lycopene group): received both ethanol and lycopene in the same dose and manner as in group II and III. After 3 weeks from the onset of the study, sections from the fundus of the stomach were processed histologically and immunohistochemically. Morphometric and statistical analysis were applied. Results: Group III revealed sloughing of the surface epithelial cells and Inflammatory cellular infiltration. Some partial cells and chief cells showed dark nuclei. Additionally, group III revealed a highly significant increase in the area % cleaved caspase 3 versus groups I and II. Group IV demonstrated an improvement in the stomach fundus's structural integrity. Conclusion: This study showed that in a model of ethanol-induced gastritis, lycopene may have a gastroprotective effect. | ||||
| Keywords | ||||
| Gastritis; Lycopene; gastric mucosa; cleaved caspase 3 | ||||
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