Correlation between theophylline level and troponin I versus kinase MB as predictor markers of the severity and outcomes in acute theophylline toxicity in adults
Nady Abdel Hafiz, H., Mahmoud, S., El helaly, H. (2025). Correlation between theophylline level and troponin I versus kinase MB as predictor markers of the severity and outcomes in acute theophylline toxicity in adults. EKB Journal Management System, 45(2), 63-76. doi: 10.21608/ajfm.2025.375847.1166
Hadeer Nady Abdel Hafiz; Suzan Mostafa Mahmoud; Hend Mohamed abdelrahman El helaly. "Correlation between theophylline level and troponin I versus kinase MB as predictor markers of the severity and outcomes in acute theophylline toxicity in adults". EKB Journal Management System, 45, 2, 2025, 63-76. doi: 10.21608/ajfm.2025.375847.1166
Nady Abdel Hafiz, H., Mahmoud, S., El helaly, H. (2025). 'Correlation between theophylline level and troponin I versus kinase MB as predictor markers of the severity and outcomes in acute theophylline toxicity in adults', EKB Journal Management System, 45(2), pp. 63-76. doi: 10.21608/ajfm.2025.375847.1166
Nady Abdel Hafiz, H., Mahmoud, S., El helaly, H. Correlation between theophylline level and troponin I versus kinase MB as predictor markers of the severity and outcomes in acute theophylline toxicity in adults. EKB Journal Management System, 2025; 45(2): 63-76. doi: 10.21608/ajfm.2025.375847.1166

Correlation between theophylline level and troponin I versus kinase MB as predictor markers of the severity and outcomes in acute theophylline toxicity in adults

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Volume 45, Issue 2, July 2025, Page 63-76  XML PDF (1.41 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2025.375847.1166
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Authors
Hadeer Nady Abdel Hafiz email 1; Suzan Mostafa Mahmoud2; Hend Mohamed abdelrahman El helaly2
1forensic medicine and clinical toxicology department, Ain Shams University
2Forensic medicine and clinical toxicology department, Ain Shams University
Abstract
Background: Theophylline, a methylxanthine, remains commonly used in several countries to manage both acute and chronic bronchial asthma. It remains popular due to its effectiveness, affordability, and widespread availability. Acute theophylline toxicity remains a significant hazard due to the absence of a specific antidote. There is a significant need to predict the severity and outcomes of patients with acute theophylline poisoning to guide appropriate treatment. Methods: This prospective cohort study included 34 patients admitted to the Poison Control Center at Ain Shams University Hospitals (PCC-ASUH) over a 6-month period from January to June 2022 with a history of acute theophylline poisoning. Troponin I and creatine kinase-MB levels were assessed at 6 and 12 hours after admission. Results showed that troponin I levels at 6 and 12 hours post ingestion, along with creatine kinase-MB levels at 12 hours, were significantly elevated in patients with severe acute theophylline poisoning and in those who required intensive care unit admission and hemodialysis. Conclusion: Troponin I can predict severity, need for ICU admission, and hemodialysis in acute theophylline poisoning regardless of early or delayed presentation, while CK-MB may serve as a predictor in patients presenting late. Recommendation: Troponin is recommended as a predictor of severity in acute intoxicated patients in early and delayed presentation. CKMB use as a predictor of severity in acute intoxicated patients in delayed presentation.
Keywords
Theophylline; Acute poisoning; Troponin I; Creatine kinase-MB; cardiotoxicity
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