Ameliorative Effect of Vitamin C against Aspartame Induced Histological Changes in Testis of Adult Male Albino Rats
El-Helbawy, N. (2025). Ameliorative Effect of Vitamin C against Aspartame Induced Histological Changes in Testis of Adult Male Albino Rats. EKB Journal Management System, 3(2), 69-92. doi: 10.21608/ejctr.2025.381235.1030
Nehal Farid El-Helbawy. "Ameliorative Effect of Vitamin C against Aspartame Induced Histological Changes in Testis of Adult Male Albino Rats". EKB Journal Management System, 3, 2, 2025, 69-92. doi: 10.21608/ejctr.2025.381235.1030
El-Helbawy, N. (2025). 'Ameliorative Effect of Vitamin C against Aspartame Induced Histological Changes in Testis of Adult Male Albino Rats', EKB Journal Management System, 3(2), pp. 69-92. doi: 10.21608/ejctr.2025.381235.1030
El-Helbawy, N. Ameliorative Effect of Vitamin C against Aspartame Induced Histological Changes in Testis of Adult Male Albino Rats. EKB Journal Management System, 2025; 3(2): 69-92. doi: 10.21608/ejctr.2025.381235.1030

Ameliorative Effect of Vitamin C against Aspartame Induced Histological Changes in Testis of Adult Male Albino Rats

Egyptian Journal of Cell and Tissue Research
Volume 3, Issue 2, June 2025, Pages 69-92    PDF (993.84 K)
Document Type: Original articles
DOI: 10.21608/ejctr.2025.381235.1030
Author
Nehal Farid El-Helbawy*
Anatomy and Embryology, Faculty of Medicine, Tanta University, Egypt
Abstract
Background: Vitamin C is a widely used antioxidant. Aspartame has been used in diet and beverages to avoid obesity. Aspartame is associated by multiple disorders multiple disorders. Aim of the work: To clarify the ameliorative effect of vitamin C against aspartame induced histological changes in testis of adult male albino rats using light and electron microscopic examination. Materials and methods: Twenty four adult male albino rats were divided into three groups (8 rats each): Group I (control): were given 2 ml distilled water daily orally. Group II (Aspartme group): were given 40 mg/kg body weight of ASP once daily dissolved in distilled water by gavage needle. Group III (Aspartame and vit. C group): were given 40 mg/kg body weight ASP plus 150 mg/kg body weight of vit C once daily dissolved in distilled water by gavage needle. All rats were given treatment for 90 consecutive days then sacrificed. Results: Group II revealed a highly significant decrease in body weight compared with group I. Group III showed a significant decrease in body weight compared with group I. Group II and group III showed a non significant difference in body weight. Histopathological changes of testes were noticed in group II. Group III revealed improvement in the structure of the testes. Conclusion: This study highlights that Vitamin C is able to improve the histological changes induced by aspartame on the testes and also ameliorate spermatogenesis.
Keywords
Aspartame; Vitamin C
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