Role of Spirulina Extract in Ameliorating Histological and Ultrastructural Changes Induced by Sodium Benzoate in the Renal Cortex of Adult Male Albino Rats
El-Helbawy, N. (2025). Role of Spirulina Extract in Ameliorating Histological and Ultrastructural Changes Induced by Sodium Benzoate in the Renal Cortex of Adult Male Albino Rats. EKB Journal Management System, 3(2), 93-112. doi: 10.21608/ejctr.2025.383087.1031
Nehal Farid El-Helbawy. "Role of Spirulina Extract in Ameliorating Histological and Ultrastructural Changes Induced by Sodium Benzoate in the Renal Cortex of Adult Male Albino Rats". EKB Journal Management System, 3, 2, 2025, 93-112. doi: 10.21608/ejctr.2025.383087.1031
El-Helbawy, N. (2025). 'Role of Spirulina Extract in Ameliorating Histological and Ultrastructural Changes Induced by Sodium Benzoate in the Renal Cortex of Adult Male Albino Rats', EKB Journal Management System, 3(2), pp. 93-112. doi: 10.21608/ejctr.2025.383087.1031
El-Helbawy, N. Role of Spirulina Extract in Ameliorating Histological and Ultrastructural Changes Induced by Sodium Benzoate in the Renal Cortex of Adult Male Albino Rats. EKB Journal Management System, 2025; 3(2): 93-112. doi: 10.21608/ejctr.2025.383087.1031

Role of Spirulina Extract in Ameliorating Histological and Ultrastructural Changes Induced by Sodium Benzoate in the Renal Cortex of Adult Male Albino Rats

Egyptian Journal of Cell and Tissue Research
Volume 3, Issue 2, June 2025, Page 93-112  XML PDF (840.78 K)
Document Type: Original articles
DOI: 10.21608/ejctr.2025.383087.1031
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Author
Nehal Farid El-Helbawy email
Anatomy and Embryology, Faculty of Medicine, Tanta University, Egypt
Abstract
Background: Spirulina is a blue green algae used as a food supplement. Sodium benzoate is used as a food preservative. Aim of the work: To assess the role of spirulina extract in ameliorating histological and ultrastructural changes induced by sodium benzoate in the kidney of adult male albino rats. Materials and methods: Thirty two adult male albino rats divided into four groups (8 rats each):  
Group I (control): received 1ml of distilled water daily.
Group II (Spirulina):  received 1ml of prepared spirulina solution 500 mg/kg/day orally.
Group III (Sodium benzoate): received 600 mg/kg body weight sodium benzoate daily dissolved in distilled water orally.
Group IV (Sodium Benzoate+ Spirulina group): received both sodium benzoate and spirulina in the same dose and manner as group II and group III .
All rats were given treatment orally once daily for 28 consecutive days then renal specimens were processed for light and electron microscopic study. Results: Group III showed significant increase in body weight compared with group I and group II. Group II and group IV showed non significant decrease in body weight compared to group III. Histopathological changes of renal cortex were noticed in group III. Group IV revealed improvement in the renal cortical tissue. Conclusion: Sodium benzoate increases the body weight and has hazardous effects on the histology of the renal cortex. While, Spirulina extract can ameliorate histopathological changes induced by sodium benzoate in renal cortex. Thus, Spirulina can be used as a Therapeutic agent to treat the renal cortex from sodium benzoate induced injury. 
Keywords
Sodium benzoate; Spirulina; renal cortex; histological; ultrastructural
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