Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia
Hassan, M., El-Taweel, A., Gohary, Y. (2025). Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia. EKB Journal Management System, 6(3), 142-156. doi: 10.21608/ejmr.2025.328433.1716
Mona Saied Hassan; Abd-Elaziz Ibrahim El-Taweel; Yasser Mostafa Gohary. "Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia". EKB Journal Management System, 6, 3, 2025, 142-156. doi: 10.21608/ejmr.2025.328433.1716
Hassan, M., El-Taweel, A., Gohary, Y. (2025). 'Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia', EKB Journal Management System, 6(3), pp. 142-156. doi: 10.21608/ejmr.2025.328433.1716
Hassan, M., El-Taweel, A., Gohary, Y. Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia. EKB Journal Management System, 2025; 6(3): 142-156. doi: 10.21608/ejmr.2025.328433.1716

Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia

Egyptian Journal of Medical Research
Volume 6, Issue 3, July 2025, Page 142-156  XML PDF (784.7 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2025.328433.1716
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Authors
Mona Saied Hassan email 1; Abd-Elaziz Ibrahim El-Taweel2; Yasser Mostafa Goharyorcid 3
1M.B.B.Ch. The October 6 University, 2013
2Dermatology, Venereology and Andrology Faculty of Medicine, Benha University
3Dermatology, Venerology and Andrology Faculty of Medicine, Beni-Suef University
Abstract
Background: Androgenetic alopecia is a leading dermatology clinic complaint. Perceptions by others can have a major psychological impact on sufferers. The disease causes hair follicle shrinking. In this complex disease, androgens, genes, and environment contribute. Objectives: This study compares monofilament threads versus platelet-rich plasma intradermal injection for AGA therapy efficacy and safety. Method: in this randomized clinical trial, we enrolled 15 male and 15 female patients diagnosed androgenetic alopecia. Left and right sides of each patient's head were cleaned with 70% alcohol without local anesthesia. In three 30-day intervals, 0.2 mL·cm−2 interfollicular A-PRP injections were administered to the left side of the scalp at a depth of 5 mm, the patient received right-sided monofilament threads. Results: Male participants averaged 21–36 years old. Onset averaged 17–32 years old. All instances had positive family histories and progressive illness onset. PRP significantly increased hair density and diameter after intervention compared to monofilament. PRP considerably increased hair diameter and density more than monofilament. Sex had no significant effect on follow-up hair density, diameter, or percent increase in monofilament or PRP groups. After 3 months, PRP monofilament group patients' age and hair density correlated linearly negatively. Conclusion: In terms of facilitating hair repair, PRP and PDO seem to be a risk-free therapy with great promise. When comparing the two treatments, PRP dramatically improved hair density and thickness compared to PDO thread implantation.
Keywords
Monofilament Threads; PRP; Androgenetic Alopecia
References
[1] Wang S, Xu S, Wang S, Fang W, Shi W. Risk factors and lipid metabolism characteristics of early-onset male androgenetic alopecia: A pilot study. J Cosmet Dermatol. 2024 May 13. doi: 10.1111/jocd.16371. Epub ahead of print. PMID: 38738464.

[2] Valente Duarte de Sousa IC, Tosti A. New investigational drugs for androgenetic alopecia. Expert Opin Investig Drugs. 2013 May;22(5):573-89. doi: 10.1517/13543784.2013.784743. Epub 2013 Apr 4. Erratum in: Expert Opin Investig Drugs. 2015 May;24(5):735. doi: 10.1517/13543784.2015.1027859. PMID: 23550739.

[3] Canfield D. Photographic documentation of hair growth in androgenetic alopecia. Dermatol Clin. 1996 Oct;14(4):713-21. doi: 10.1016/s0733-8635(05)70397-1. PMID: 9238329.

[4] Ramos PM, Miot HA. Female Pattern Hair Loss: a clinical and pathophysiological review. An Bras Dermatol. 2015 Jul-Aug;90(4):529-43. doi: 10.1590/abd1806-4841.20153370. PMID: 26375223; PMCID: PMC4560543.

[5] Olsen EA, Messenger AG, Shapiro J, Bergfeld WF, Hordinsky MK, Roberts JL, Stough D, Washenik K, Whiting DA. Evaluation and treatment of male and female pattern hair loss. J Am Acad Dermatol. 2005 Feb;52(2):301-11. doi: 10.1016/j.jaad.2004.04.008. PMID: 15692478.

[6] Kim YS, Jeong KH, Kim JE, Woo YJ, Kim BJ, Kang H. Repeated Microneedle Stimulation Induces Enhanced Hair Growth in a Murine Model. Ann Dermatol. 2016 Oct;28(5):586-592. doi: 10.5021/ad.2016.28.5.586. Epub 2016 Sep 30. PMID: 27746638; PMCID: PMC5064188.

[7] Justicz N, Derakhshan A, Chen JX, Lee LN. Platelet-Rich Plasma for Hair Restoration. Facial Plast Surg Clin North Am. 2020 May;28(2):181-187. doi: 10.1016/j.fsc.2020.01.009. Epub 2020 Mar 2. PMID: 32312505.

[8] Bharti J, Sonthalia S, Patil P, Dhurat R. Scalp threading with polydioxanone monofilament threads: a novel, effective and safe modality for hair restoration. J Eur Acad Dermatol Venereol. 2017 Nov;31(11):e492-e493. doi: 10.1111/jdv.14336. Epub 2017 Jul 3. PMID: 28502076.

[9] Ross EK, Vincenzi C, Tosti A. Videodermoscopy in the evaluation of hair and scalp disorders. J Am Acad Dermatol. 2006 Nov;55(5):799-806. doi: 10.1016/j.jaad.2006.04.058. Epub 2006 Jul 28. PMID: 17052485.

[10] Devjani S, Ezemma O, Kelley KJ, Stratton E, Senna M. Androgenetic Alopecia: Therapy Update. Drugs. 2023 Jun;83(8):701-715. doi: 10.1007/s40265-023-01880-x. Epub 2023 May 11. PMID: 37166619; PMCID: PMC10173235.

[11] Khattab FM, Bessar H. Accelerated hair growth by combining thread monofilament and minoxidil in female androgenetic alopecia. J Cosmet Dermatol. 2020 Jul;19(7):1738-1744. doi: 10.1111/jocd.13228. Epub 2019 Dec 2. PMID: 31789457.

[12] Sharma A, Chouhan K, Bhatia S, Dashore S. Platelet-Rich Plasma in Androgenetic Alopecia. Indian Dermatol Online J. 2021 Nov 25;12(Suppl 1):S31-S40. doi: 10.4103/idoj.idoj_328_21. PMID: 34976879; PMCID: PMC8664169.

[13] Gentile P, Garcovich S. Autologous activated platelet-rich plasma (AA-PRP) and non-activated (A-PRP) in hair growth: a retrospective, blinded, randomized evaluation in androgenetic alopecia. Expert Opin Biol Ther. 2020 Mar;20(3):327-337. doi: 10.1080/14712598.2020.1724951. Epub 2020 Feb 14. PMID: 32011196.

[14] IM, A.K., MK, I. and Sherif, M.E., 2023. Evaluation of efficacy and safety of scalp threading with polydioxanone (PDO) monofilament threads in the treatment of male androgenetic alopecia. Al-Azhar International Medical Journal, 4(11), p.10.

[15] Śliwa, K., Synia, D., Placek, W. and Owczarczyk-Saczonek, A., 2023, August. The diagnosis and treatment of androgenetic alopecia: a review of the most current management. In Forum Dermatologicum.

[16] Dhurat R, Sukesh M. Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):189-97. doi: 10.4103/0974-2077.150734. PMID: 25722595; PMCID: PMC4338460.

[17] Gaviño Orduña JF, Caviedes-Bucheli J, Manzanares Céspedes MC, Berástegui Jimeno E, Martín Biedma B, Segura-Egea JJ, López-López J. Use of Platelet-rich Plasma in Endodontic Procedures in Adults: Regeneration or Repair? A Report of 3 Cases with 5 Years of Follow-up. J Endod. 2017 Aug;43(8):1294-1301. doi: 10.1016/j.joen.2017.04.010. Epub 2017 Jun 27. PMID: 28662879.

[18] Gupta M, Mysore V. Classifications of Patterned Hair Loss: A Review. J Cutan Aesthet Surg. 2016 Jan-Mar;9(1):3-12. doi: 10.4103/0974-2077.178536. PMID: 27081243; PMCID: PMC4812885.

[19] Cervantes J, Perper M, Wong LL, Eber AE, Villasante Fricke AC, Wikramanayake TC, Jimenez JJ. Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature. Skin Appendage Disord. 2018 Jan;4(1):1-11. doi: 10.1159/000477671. Epub 2017 Jun 24. PMID: 29457005; PMCID: PMC5806173.

[20] Surowiecka A, Strużyna J. Adipose-Derived Stem Cells for Facial Rejuvenation. J Pers Med. 2022 Jan 16;12(1):117. doi: 10.3390/jpm12010117. PMID: 35055432; PMCID: PMC8781097.

[21] Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014 Oct-Dec;7(4):213-9. doi: 10.4103/0974-2077.150743. PMID: 25722600; PMCID: PMC4338465.

[22] Navarro, M.R., Asín, M., Martínez, M.A., Martínez, A.M., Molina, C., Moscoso, L., Pino, A., Orive, G. and Anitua, E., 2016. Management of androgenetic alopecia: a comparative clinical study between plasma rich in growth factors and topical minoxidil. European Journal of Plastic Surgery, 39, pp.173-180.

[23] Alves R, Grimalt R. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia. Dermatol Surg. 2016 Apr;42(4):491-7. doi: 10.1097/DSS.0000000000000665. PMID: 27035501.

[24] Starace M, Alessandrini A, D'Acunto C, Melandri D, Bruni F, Patrizi A, Piraccini BM. Platelet-rich plasma on female androgenetic alopecia: Tested on 10 patients. J Cosmet Dermatol. 2019 Feb;18(1):59-64. doi: 10.1111/jocd.12550. Epub 2018 Apr 30. PMID: 29707872.

[25] Butt G, Hussain I, Ahmed FJ, Choudhery MS. Efficacy of platelet-rich plasma in androgenetic alopecia patients. J Cosmet Dermatol. 2019 Aug;18(4):996-1001. doi: 10.1111/jocd.12810. Epub 2018 Nov 4. PMID: 30393988.

[26] Wang JC, Fort CL, Matl CM, Harvey BD, Demke JC, Thomas JR, Sidle DM. Effects of Essential Oils on Scars and Wound Healing: A Systematic Review. Facial Plast Surg. 2023 Apr;39(2):173-179. doi: 10.1055/a-1938-0343. Epub 2022 Sep 7. PMID: 36070793.

[27] Dicle Ö, Bilgic Temel A, Gülkesen KH. Platelet-rich plasma injections in the treatment of male androgenetic alopecia: A randomized placebo-controlled crossover study. J Cosmet Dermatol. 2020 May;19(5):1071-1077. doi: 10.1111/jocd.13146. Epub 2019 Sep 18. PMID: 31532574.

[28] Mapar MA, Shahriari S, Haghighizadeh MH. Efficacy of platelet-rich plasma in the treatment of androgenetic (male-patterned) alopecia: A pilot randomized controlled trial. J Cosmet Laser Ther. 2016 Dec;18(8):452-455. doi: 10.1080/14764172.2016.1225963. Epub 2016 Oct 13. PMID: 27593381.

[29] Puig CJ, Reese R, Peters M. Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia. Dermatol Surg. 2016 Nov;42(11):1243-1247. doi: 10.1097/DSS.0000000000000883. PMID: 27608205.

[30] Ayatollahi A, Hosseini H, Shahdi M, AhmadNasrollahi S, NassiriKashani M, Yadangi S, Firooz FH, Firooz A. Platelet-rich Plasma by Single Spin Process in Male Pattern Androgenetic Alopecia: Is it an Effective Treatment? Indian Dermatol Online J. 2017 Nov-Dec;8(6):460-464. doi: 10.4103/idoj.IDOJ_11_17. PMID: 29204389; PMCID: PMC5707838.

[31] Gressenberger P, Pregartner G, Gary T, Wolf P, Kopera D. Platelet-rich Plasma for Androgenetic Alopecia Treatment: A Randomized Placebo-controlled Pilot Study. Acta Derm Venereol. 2020 Aug 18;100(15):adv00247. doi: 10.2340/00015555-3609. PMID: 32735021; PMCID: PMC9207632.

[32] Metwalli M, Khattab FM, Mandour S. Monofilament threads in treatment of female hair loss. J Dermatolog Treat. 2021 Aug;32(5):521-525. doi: 10.1080/09546634.2019.1682499. Epub 2020 Mar 3. PMID: 31619089.

[33] Giordano S, Romeo M, di Summa P, Salval A, Lankinen P. A Meta-analysis On Evidence Of Platelet-rich Plasma for Androgenetic Alopecia. Int J Trichology. 2018 Jan-Feb;10(1):1-10. doi: 10.4103/ijt.ijt_74_16. PMID: 29440850; PMCID: PMC5803844.

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