A Comparative Analysis of Serum E-selectin levels Between Psoriatic Patients and Controls | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Volume 35, Issue 1, January 2026 | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
| DOI: 10.21608/ejmm.2025.400593.1758 | ||||
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| Authors | ||||
Noor S. Abd  ; Hawraa A. Mubark
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| Department of Microbiology, College of Medicine, University of Kufa, Najaf, Iraq | ||||
| Abstract | ||||
| Background: Psoriasis is a chronic autoimmune skin disease characterized by a dysregulated immune response that leads to persistent inflammation and abnormal proliferation of keratinocytes. One of the key events in the development of psoriatic lesions is the infiltration of leukocytes into the skin, which is mediated by adhesion molecules such as E-selectin. E-selectin is expressed on activated endothelial cells in response to pro-inflammatory cytokines, and it facilitates the initial tethering and rolling of leukocytes along the vascular endothelium. In psoriasis, elevated expression of E-selectin enhances the recruitment of neutrophils and T cells to the inflamed skin, thereby contributing to the maintenance and exacerbation of the inflammatory response. We hypothesize that serum levels of E-selectin may be elevated in Iraqi patients with psoriasis compared to healthy individuals, and that it may have a potential role as a diagnostic biomarker. Objective: The purpose of this study was to assess the soluble E-selectin (sE-selectin) levels in Iraqi patients with psoriasis and analyze its diagnostic potential role by comparing these levels with healthy control subjects. Methodology: In this study, a case-control design was conducted on 130 individuals. The patient group, comprising 65 individuals diagnosed with psoriasis and 65 apparently healthy individuals as the control group. The participants’ ages ranged from 18 to 70 years. Blood specimens were obtained after acquiring verbal permission. The ELISA technique was used to measure the serum levels of E-selectin. Results: The mean serum of E-Selectin concentration was 278.6±48.6 ng/mL in the psoriatic group and 89.3±14.2 ng/mL in the healthy group. Patients had significantly higher amounts than healthy people, and this difference was statistically significant. (P < 0.001). Conclusion: E-selectin serum levels were significantly elevated in psoriasis patients and may serve as a useful biomarker for disease monitoring and prognosis. Its serum levels reflect endothelial activation and disease activity, supporting its potential role in clinical assessment. | ||||
| Keywords | ||||
| Psoriasis; E-selectin; Serum Biomarker; Diagnosis; Endothelial Activation | ||||
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