THERAPEUTIC PROTOCOL AND MANAGEMENT OF EXPERIMENTALLY-INDUCED HYPERLIPIDEMIA IN DONKEYS (EQUUS ASINUS) | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 23, Volume 71, Issue 186, July 2025, Page 291-305 PDF (1.12 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.2025.361887.1592 | ||||
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| Authors | ||||
ABEER ABD EL-WARES MAHMOUD  ; HUSSEIN AWAD HUSSEIN  ; HANAN KAMAL ELSAYED
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| Veterinary Internal Medicine, Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt. | ||||
| Abstract | ||||
| Equines are more affected by lipid metabolism disturbances (hyperlipidemia), and donkeys are especially susceptible to hyperlipidemia. It is usually a primary disease process, and stress and obesity appear to be important predisposing factors or secondary diseases due to any disease that results in a negative energy balance. Treatment is critical as quickly as possible, including fluid therapy (mainly Dextrose 5%) and insulin injections. The study was set up as a prospective, observational and experimental trial including 10 donkeys. The experiment period (10 days) consisted of two stages. In the fasting stage (4 days) and the post-fasting stage (6 days), the treatment was administered for 3 days. On six occasions, the following were determined according to the effect of hyperlipidemia and its therapy: body weight, body condition score, ultrasound subcutaneous croup fat thickness (CFT), liver ultrasonography, and blood metabolites. The ultrasound CFT was significantly decreased at the fasting stage (P<0.05). Hepatic ultrasonography showed no changes. The portal vein (PV) diameter decreased during the 4 days of fasting. The hepatic relative echogenicity (RE) significantly increased during fasting (P<0.05). The lipid profile showed an increase in all parameters during fasting. The plasma glucose decreased during the fasting period (P<0.05) and increased in the post-fasting stage (P<0.05). The serum levels of FFAs and liver enzymes increased significantly (P<0.05). In conclusion, quick intervention with therapy and management in cases of hyperlipidemia helps easily correct any abnormalities that occur in the animal body due to a negative energy balance state. | ||||
| Keywords | ||||
| Treatment; Croup fat thickness; hyperlipidemia; donkeys; liver echogenicity; FFAs | ||||
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