NUTROTHERAPEUTIC EFFECTS OF HYPERICUM PERFORATUM (HYPERICUM PERFORATUM L.) POWDER AND EXTRACT CONSUMPTION TO IMPROVE HORMONAL DISORDERS SYMPTOMS ON ELDERLY FEMALE RATS | ||||
| مجلة بحوث التربية النوعية | ||||
| Volume 2025, Issue 92, May 2025, Page 1303-1324 PDF (369.66 K) | ||||
| Document Type: مقالات علمیة محکمة | ||||
| DOI: 10.21608/mbse.2025.444749 | ||||
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| Authors | ||||
عبد الغني محمود عبد الغني 1; هناء فاروق محمد المهيري2; لبنى احمد شلباية2; عزة عبدالعظيم رزق
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| 1کلية التربية النوعية جامعة المنصورة | ||||
| 2كلية التربية النوعية جامعة المنصورة | ||||
| Abstract | ||||
| The current study aims to identify the effect of consuming hypericum perforatum powder and extract in improving symptoms of hormonal disorders in elderly female rats, The study was conducted on Twenty-eight female Sprague Dawley rats, classified into four groups (7 rats each) seven young adult female rats, three month-old and weighting 200± 15g as negative control rat group and twenty-one aged female rats (18- 20-month-old, 300 ± 15g) were divided into three groups positive control group fed on basal diet only , group which consumed hypericum perforatum powder (HPP) as 15% mixed into basal diet and group administered hypericum perforatum water extract (HPE) at a dose of 1300 mg/kg body weight daily via oral gavage. The experiment period was 60 days. The obtained Chemical results of phenolic compounds analysis of hypericum perforatum, showed that it the highest amount of e-vanillic, pyrogallol, iso-ferulic and epi-catechin their content were 1198.19, 444.11, 275.73, and 215.89 ppm respectively. The biological study showed that consumption of HPP or HPE Proved that the significant increase in body weight gain (BWG), feed efficiency ratio (FER), serum high density lipoprotein cholesterol, (HDL-c), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone(P4) on the other hand a significant decrease in total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c) and very low density lipoprotein cholesterol (VLDL-c) and testosterone hormone compared to positive control rat groups. It concluded that consumption of hypericum perforatum has a best treatment to improve hormonal disorders symptoms in aged menopausal female rats, should be placed within their diet plan for aged female, to protect their health from hormonal imbalances resulting from aging. | ||||
| Keywords | ||||
| Hypericum perforatum; Antioxidant activities; Menopause – Phytoestrogens; Hormonal imbalance –aged female rats | ||||
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