Evaluating the Efficacy of Paclitaxel in Reducing Neointimal Hyperplasia Following Peripheral Vascular Intervention | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Articles in Press, Accepted Manuscript, Available Online from 30 July 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2025.398456.2609 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Osman Mahmoud1; Mahmoud Saleh1; Hassan Elbadawy1; Ahmed Nageeb   2
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| 1Faculty of medicine Assiut university hospitals Department of Vascular and Endovascular surgery | ||||
| 2Faculty of medicine Assiut university hospitals Department of Vascular and Endovascular surgery | ||||
| Abstract | ||||
| Abstract Background: Randomized trials in treating CLTI have demonstrated the effectiveness of paclitaxel-coated balloons (PCBs) in femoropopliteal disease. The article attempts to provide a survey of our observations concerning the paclitaxel-coated balloon to treat lesions in the femoropopliteal arteries. Methods: A single-arm trial was conducted involving 46 femoropopliteal lesions treated with PCB to gather data over an average follow-up period of two years. The endpoints assessed included primary patency at 12 months and late lumen loss (LLL) at 6 months and all-cause mortality at 12 months. Results: Technical success achieved 100%. The average lesion length is 107.1 ± 42 mm. The overall primary patency was 79.4% at one year. The mean late lumen loss was -0.35 mm, with a range of 0.07 to 0.51 mm. Conclusion: These findings indicate that the paclitaxel antimitotic drug is safe and effective for treating femoropopliteal artery disease. Keywords: Paclitaxel-coated balloon, Femoropopliteal artery, chronic limb-threatening ischemia | ||||
| Keywords | ||||
| Paclitaxel-coated balloon; Femoropopliteal artery; chronic limb-threatening ischemia | ||||
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