Spectrophotometric Determination of Ambroxol by Chromotropic acid disodium salt dihydrate | ||
| Journal of Bioscience and Applied Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 31 July 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.374970.1185 | ||
| Authors | ||
| Riyadh R. Al - Araji1; Abd Ali Abd Al-Hussein Shalan Al-Mushhdi2; mohauman M majeed* 3 | ||
| 1Department of Biology, College of Education for Pure Science, University of Wasit, Wasit, Iraq. | ||
| 2Chemistry Department, Najaf Central Preparatory School for Boys, Ministry of Education, Iraq | ||
| 3kufa | ||
| Abstract | ||
| An easy and prompt spectrophotometric method was proposed for the limitation of the drug ambroxol substance containing the amine group by the organic reagent (4,5-Dihydroxynaphthalene-2,7-disulfonic acid disodium salt dihydrate). When the reaction product gave a wavelength(469nm) and in optimal conditions for the reaction, a calibration curve was generated. The result was found that Beer's law obeyed within concentration ranges of 2-18µg.mL-1 of ambroxol and the other parameter was calculated. The molar absorptivity was 0.8287X104 L.mol-1.cm-1, Sandell's sensitivity was 0.0128 μg.cm-2, R.S.D% was 0.6520 %, with a correlation coefficient of 0.9967 for ambroxol. The interferences were studied; they didn't affect on concentration limitation of ambroxol. The method was successfully applied for determination of ambroxol in drug pharmaceutical. Amino compounds can be classified as organic compounds where the amine group is linked to carbon groups, and the hydrogen atom in the ammonia compound is replaced by an organic group such as an aryl or alkyl. Amines can be classified into three types: primary, secondary, and tertiary amines, as shown in the Fig. below (Fig. 1). There is another class of amino compounds called quaternary ammonium ions, which | ||
| Keywords | ||
| Ambroxol; Chromotropic acid disodium salt dihydrate; spectrophotometry; pharmaceutical formulation | ||
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