Spectrophotometric Determination of Ambroxol by Chromotropic acid disodium salt dihydrate | ||
| Journal of Bioscience and Applied Research | ||
| Article 21, Volume 11, Issue 3, September 2025, Pages 962-975 PDF (1.29 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbaar.2025.374970.1185 | ||
| Authors | ||
| Riyadh R. Al - Araji1; Abd Ali Abd Al-Hussein Shalan Al-Mushhdi2 | ||
| 1Department of Biology, College of Education for Pure Science, University of Wasit, Wasit, Iraq. | ||
| 2Chemistry Department, Najaf Central Preparatory School for Boys, Ministry of Education, Iraq | ||
| Abstract | ||
| An easy and prompt spectrophotometric method was proposed for the limitation of the drug Ambroxol substance containing the amine group by the organic reagent (4,5-Dihydroxynaphthalene-2,7-disulfonic acid disodium salt dihydrate). When the reaction product gave a wavelength(469nm), and in optimal conditions for the reaction, a calibration curve was generated. The result was found that Beer's law was obeyed within concentration ranges of 2-18µg.mL-1 of Ambroxol, and the other parameter was calculated. The molar absorptivity was 0.8287X104 L.mol-1.cm-1, Sandell's sensitivity was 0.0128 μg.cm-2, R.S.D% was 0.6520 %, with a correlation coefficient of 0.9967 for Ambroxol. The interferences were studied; they didn't affect on concentration limitation of Ambroxol. The method was successfully applied for the determination of Ambroxol in pharmaceuticals. | ||
| Keywords | ||
| Ambroxol; Chromotropic acid disodium salt dihydrate; spectrophotometry; pharmaceutical formulation | ||
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