Effect of Topical Insulin on Wound Healing in Diabetic Foot Ulcer | ||||
| Zagazig University Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 01 August 2025 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2025.400156.4035 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Aymen Mohamed Samir1; Mohamed Ahmed Effat1; Ahmed Ibrahim Mohamed Waked  2; Ahmed Mohamed Abdelkareem Gomaa3
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| 1Professor of Vascular Surgery, Faculty of Medicine, Zagazig University, Egypt. | ||||
| 2Department of vascular Surgery, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Lecturer of General Surgery, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Diabetic foot ulcers (DFU) are a serious side effect of diabetes mellitus that are associated with high rates of morbidity, mortality, and medical costs worldwide. The purpose of this study was to determine the optimal topical insulin dressing technique for diabetic foot ulcers in terms of the amount of time needed for ulcer healing and the effectiveness of insulin in comparison to conventional techniques. Methods: This prospective clinical trial was conducted at the Vascular Surgery Department, Zagazig University Hospitals, included 42 diabetic foot ulcer patients randomly assigned into two equal groups: Group A received topical insulin dressing, while Group B received saline dressing. All patients underwent thorough clinical evaluation, ulcer assessment, ABPI measurement, and baseline investigations. Topical insulin dressing was applied daily for one week followed by saline dressing for three weeks, in a repeated 12-week cycle. Ulcer dimensions (area, length, width, depth) and healing progression were assessed weekly. Results: The insulin group demonstrated significantly faster and greater reductions in ulcer area, length, width, and depth starting from the second week and persisting throughout the 12-week follow-up (p<0.05). The median healing time was significantly shorter in the insulin group (40 days) compared to the saline group (66 days) (p=0.003). Notably, 61.9% of insulin-treated ulcers achieved complete healing within 30–40 days versus none in the saline group (p=0.016). Both groups maintained adequate glycemic control throughout the study without significant adverse effects. Conclusion: These findings affirm topical insulin as an optimal dressing strategy, offering enhanced efficacy and faster recovery. | ||||
| Keywords | ||||
| Diabetic foot ulcer; Topical insulin; Wound healing | ||||
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