Ameliorative role of coenzyme Q10 against simvastatin induced myopathy of skeletal muscles in adult male albino rats. | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 03 August 2025 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2025.404125.2031 | ||
| Authors | ||
| Sayed Fouad1; Fatma Alzahraa Fouad Abd Al-Baky2; Dr. Samah Abuzaid3; Elsyed Aly Mahran4; Heba Hussien* 5; Medhat Ata6 | ||
| 1Department of Anatomy, El-Minia Faculty of Medicine | ||
| 2Department of Human Anatomy & Embryology Faculty of Medicine Minia University | ||
| 3Department of Human Anatomy & Embryology, Faculty of Medicine, Minia University, | ||
| 4Department of Human Anatomy & Embryology, Faculty of Medicine, Minia University | ||
| 5Human anatomy and embryology department, Faculty of medicine, Minia university, Egypt | ||
| 6Assistant professor of Anatomy and Embryology Faculty of Medicine, Minia University | ||
| Abstract | ||
| Background: Simvastatin (SV) is one anti hyperlipidemic drugs. It acts by inhibition of HMG-CoA reductase. It can cause side effects, including muscle pain. Coenzyme Q10 (CoQ10) is present in the body as an antioxidant, as it is necessary for cell maintenance. Aim: This study was designated to evaluate the ability of CoQ10 to repair damaged skeletal muscle triggered by SV in albino rats. Material and Methods:40 adult male albino rats were used in this study, divided into 4 distinct groups; each was composed of 10 rats and received the drug diluted in distilled water via a gastric tube for a period of 12 weeks. Group I received a daily dosage of usual food and water. Group II administered SV at a dose of 10 mg/kg/day. Group III received SV at a dose of 10 mg/kg/day with CoQ10 at a dose of 10 mg/kg/day. Group IV received 10mg/kg/day of SV for 12 weeks, followed by 12weeks stopping of drug. At the end of experiment, muscle tissues of gastrocnemius were collected from groups and processed for H&E, PAS and toluidine blue. Biochemical analyses were conducted to assess levels of CK. Results: Administration of SV in group II leads to elevation in the CK with histological changes in muscle fiber in H&E, PAS and toluidine blue. On the other hand administration of CoQ10 in group III showed a significant decrease in CK, with improvement in architecture of the muscle fiber. Conclusion: CoQ10 administration improve the skeletal myopathy induced by SV. | ||
| Keywords | ||
| CoQ10; SV; CK; skeletal muscle | ||
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